Words similar to immunogenicity
Example sentences for: immunogenicity
How can you use “immunogenicity” in a sentence? Here are some example sentences to help you improve your vocabulary:
In rodents, intravenous injection of a non-targeted vector - viruses or plasmid preparations - induces mainly transfection in the liver and the spleen [ 1 2 ] . As of today, transfection of other large organs by viral vectors has not been accomplished in by way of systemic delivery [ 3 ] . The main inconveniences of intravenous administration of first generation adenoviral vectors are their immunogenicity [ 4 ] and hepatic toxicity [ 5 6 ] . The muscle as a large tissue mass is a candidate for production of recombinant protein, but the transfection is limited to the injection site.
The immunogenicity of an enzyme can be increased, while maintaining the majority of its stability and proteolytic activity, by incorporating a single amino acid change.
This difference in immunogenicity has been noted by others using an intratracheal method of immunization [ 28 29 ] .
Reduced immunogenicity was characterized as significantly lower titers of antigen-specific IgG when animals were immunized with the same amount of the enzymes.
It has been speculated that these modified forms of autoantigens may have enhanced immunogenicity through exposure of immunocryptic epitopes that are not generated during antigen processing [ 21 23 37 43 ] . These epitopes could trigger autoimmune responses if presented to the immune system under proinflammatory conditions [ 44 ] , and they may be recognized as surface structures on cytoplasmic organelles that are released to the immune system in aberrant disease states.
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