Example sentences for: immunogenicity

How can you use “immunogenicity” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The CC531 tumour is a dimethylhydrazine-induced, moderately differentiated colon adenocarcinoma exhibiting weak immunogenicity [ 40 ] . The tumour is transplantable in syngeneic Wag/Rij rats.

  • In rodents, intravenous injection of a non-targeted vector - viruses or plasmid preparations - induces mainly transfection in the liver and the spleen [ 1 2 ] . As of today, transfection of other large organs by viral vectors has not been accomplished in by way of systemic delivery [ 3 ] . The main inconveniences of intravenous administration of first generation adenoviral vectors are their immunogenicity [ 4 ] and hepatic toxicity [ 5 6 ] . The muscle as a large tissue mass is a candidate for production of recombinant protein, but the transfection is limited to the injection site.

  • By improving either peptide binding to MHC, recognition by TCRs, or both, these variants have increased peptide antigenicity and immunogenicity.

  • Due to their high immunogenicity and their extra-chromosomal replication, the current adenoviral vectors may not be appropriate for long-term transduction in-vivo but improvement in vector design and adoptive transfer into immunodeficient hosts may facilitate experiments in the future.

  • However, the inference as to the degree of sterilizing immunity from the level of immunogenicity is limited by our lack of knowledge about the mechanisms of protection against infection as such [13].


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