Words similar to immunogenicity
Example sentences for: immunogenicity
How can you use “immunogenicity” in a sentence? Here are some example sentences to help you improve your vocabulary:
The CC531 tumour is a dimethylhydrazine-induced, moderately differentiated colon adenocarcinoma exhibiting weak immunogenicity [ 40 ] . The tumour is transplantable in syngeneic Wag/Rij rats.
In rodents, intravenous injection of a non-targeted vector - viruses or plasmid preparations - induces mainly transfection in the liver and the spleen [ 1 2 ] . As of today, transfection of other large organs by viral vectors has not been accomplished in by way of systemic delivery [ 3 ] . The main inconveniences of intravenous administration of first generation adenoviral vectors are their immunogenicity [ 4 ] and hepatic toxicity [ 5 6 ] . The muscle as a large tissue mass is a candidate for production of recombinant protein, but the transfection is limited to the injection site.
By improving either peptide binding to MHC, recognition by TCRs, or both, these variants have increased peptide antigenicity and immunogenicity.
Due to their high immunogenicity and their extra-chromosomal replication, the current adenoviral vectors may not be appropriate for long-term transduction in-vivo but improvement in vector design and adoptive transfer into immunodeficient hosts may facilitate experiments in the future.
However, the inference as to the degree of sterilizing immunity from the level of immunogenicity is limited by our lack of knowledge about the mechanisms of protection against infection as such [13].