Words similar to igf-i
Example sentences for: igf-i
How can you use “igf-i” in a sentence? Here are some example sentences to help you improve your vocabulary:
Activation of the native receptor requires the trans-phosphorylation of two kinase domains [ 48 ] . Hence, expression of an excess of kinase-defective IGF-I receptors causes the formation of hybrid molecules containing one half an endogenous wild-type receptor and the other half a kinase-defective transfected receptor.
Transformation appears to involve autocrine stimulation as IGF-I production and secretion is increased in normal cells following transformation by SV40 T antigen, but the null cells cannot respond to the IGF-I so do not transform.
IGF-I can prevent c-myc -induced apoptosis in rat-l fibroblasts, and neuronal apoptosis due to serum-starvation.
Elegant studies in knockout mice have delineated the contribution of IGF-I, IGF-II and the IGF-I receptor to fetal growth [for review see ref [ 36 ] ]. Embryonic fibroblasts derived from IGF-IR knockout embryos (R-cells) do not grow in serum-free medium, despite supplementation with a wide variety of other growth factors, and grow more slowly in media containing serum than wild-type cells [for reviews see refs [ 37 38 ] ]. Additionally, all phases of the cell cycle are prolonged in the null cells suggesting that the IGF-IR is required throughout the cell cycle.
We have previously demonstrated the overexpression and hormone-independent activation of the IGF-IR in primary breast cancers [ 42 ] . Similar overexpression of the IGF-IR and the ligands IGF-I and IGF-II have been seen in human gliomas and astrocytomas [ 43 44 45 46 ] . Because of the important role for the IGF-IR in cell survival, we investigated whether a dominant negative IGF-IR could inhibit growth of the U87 glioma.
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