Example sentences for: igf-i

How can you use “igf-i” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Transformation appears to involve autocrine stimulation as IGF-I production and secretion is increased in normal cells following transformation by SV40 T antigen, but the null cells cannot respond to the IGF-I so do not transform.

  • Treatment with antagonistic peptide analogs of IGF-I, antisense oligos, or an adenovirus expressing IGF-IR antisense cRNA, prevents proliferation of cells in monolayers, transformation, and growth in athymic nude mice.

  • Initially, we tested Chinese hamster ovary (CHO) cells that had been stably transfected with expression vectors for kinase-inactive or wild type IGF-I receptors [ 53 ] . The parental CHO cell line expresses ~50,000 endogenous IGF-IRs, the transfected wild-type (CHO-WT) cell line expresses ~250,000 IGF-IRs, and the kinase-defective (CHO-MK) cell line expresses ~250,000 mutant IGF-IRs.

  • We assessed the ability of the IGF-IRs of each cell line to undergo autophosphorylation in response to increasing concentrations of IGF-I.

  • Cells were stimulated with IGF-I at the indicated concentrations for 18 h.


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