Words similar to igf-ii
Example sentences for: igf-ii
How can you use “igf-ii” in a sentence? Here are some example sentences to help you improve your vocabulary:
In addition, choroid plexus expresses insulin, IGF-I, and IGF-II receptors [ 11 47 ] ., as well as large amounts of IGF-II that is secreted into the CSF [ 47 ] . CSF contains insulin/IGFs and 5-HT [ 48 ] in concentrations high enough to activate their respective receptors in choroid plexus, suggesting that this signaling mechanism may occur in vivo . It has been suggested that 5-5HT 2C receptors in choroid plexus may be tonically activated, due to CSF 5-HT concentrations near the EC 50 , thus tonically inhibiting CSF production.
Cells were incubated at 37°C for 2 hrs in serum-free DMEM containing 125I-labeled IGF-II (0.
Because the M6P/IGF2R is believed to sequester and degrade IGF-II [ 10 ] , a decrease in M6P/IGF2R could result in decreased degradation and hence increased bioavailability of IGF-II to the IGF-I receptor, which mediates the growth-promoting effect of IGF-II.
This result suggests that the proliferative effect of M6P/IGF2R down-regulation is likely the result of unchecked IGF-II stimulation.
Modulation of this mitogenic pathway occurs in part via the M6P/IGF2R, which functions in the internalization and degradation of IGF-II [ 10 ] . M6P/IGF2R is also important in activation of TGF-β, a potent growth inhibitor for most cell types, and in binding, transport and activation of lysosomal enzymes, such as cathepsins [ 12 13 ] . It has been shown that M6P/IGF2R expression is significantly reduced in both rat and human hepatocellular carcinomas [ 14 ] . Loss of hetorozygosity (LOH) at the M6P/IGF2 receptor gene locus on 6q26-27 coupled with somatic point mutations in the remaining allele has recently been demonstrated in liver and breast cancers [ 15 16 17 18 19 20 21 22 23 ] . In addition, somatic mutations of the M6P/IGF2R gene were also found in prostate cancer, lung carcinoma, and genetically unstable cancers of the endometrium, brain, stomach and colorectum [ 24 25 26 27 28 29 ] . The findings of LOH and mutations of M6P/IGF2R in a wide variety of tumor types have led to the proposition that the M6P/IGF2R is a tumor suppressor gene.
Loading...