Words similar to igf-ii

Example sentences for: igf-ii

How can you use “igf-ii” in a sentence? Here are some example sentences to help you improve your vocabulary:

We have previously demonstrated the overexpression and hormone-independent activation of the IGF-IR in primary breast cancers [ 42 ] . Similar overexpression of the IGF-IR and the ligands IGF-I and IGF-II have been seen in human gliomas and astrocytomas [ 43 44 45 46 ] . Because of the important role for the IGF-IR in cell survival, we investigated whether a dominant negative IGF-IR could inhibit growth of the U87 glioma.
In addition, choroid plexus expresses insulin, IGF-I, and IGF-II receptors [ 11 47 ] ., as well as large amounts of IGF-II that is secreted into the CSF [ 47 ] . CSF contains insulin/IGFs and 5-HT [ 48 ] in concentrations high enough to activate their respective receptors in choroid plexus, suggesting that this signaling mechanism may occur in vivo . It has been suggested that 5-5HT 2C receptors in choroid plexus may be tonically activated, due to CSF 5-HT concentrations near the EC 50 , thus tonically inhibiting CSF production.
Supporting evidence for the involvement of IGF-II in the proliferative effect resulting from loss of M6P/IGF2R function comes from studies of M6P/IGF2R knock-out mice.
After infection with Ad-GFP/IGF2R-Rz or Ad-GFP, cells were incubated with or without 50 ng/ml IGF-II for 4 days.
Noticeably, the effect of ribozyme expression on cell growth was more apparent in the presence of IGF-II.