Words similar to igf-ii
Example sentences for: igf-ii
How can you use “igf-ii” in a sentence? Here are some example sentences to help you improve your vocabulary:
Because the M6P/IGF2R is believed to sequester and degrade IGF-II [ 10 ] , a decrease in M6P/IGF2R could result in decreased degradation and hence increased bioavailability of IGF-II to the IGF-I receptor, which mediates the growth-promoting effect of IGF-II.
Ad-GFP, adenovirus carrying GFP gene; Ad-GFP/Rz-IGF2R, adenovirus carrying both ribozyme against M6P/IGF2R and GFP gene; GFP, green fluorescent protein; IGF-II, insulin-like growth factor II; M6P/IGF2R, mannose 6-phosphate/insulin-like growth factor II receptor; Rz, ribozyme, TGF-β transforming growth factor beta.
Modulation of this mitogenic pathway occurs in part via the M6P/IGF2R, which functions in the internalization and degradation of IGF-II [ 10 ] . M6P/IGF2R is also important in activation of TGF-β, a potent growth inhibitor for most cell types, and in binding, transport and activation of lysosomal enzymes, such as cathepsins [ 12 13 ] . It has been shown that M6P/IGF2R expression is significantly reduced in both rat and human hepatocellular carcinomas [ 14 ] . Loss of hetorozygosity (LOH) at the M6P/IGF2 receptor gene locus on 6q26-27 coupled with somatic point mutations in the remaining allele has recently been demonstrated in liver and breast cancers [ 15 16 17 18 19 20 21 22 23 ] . In addition, somatic mutations of the M6P/IGF2R gene were also found in prostate cancer, lung carcinoma, and genetically unstable cancers of the endometrium, brain, stomach and colorectum [ 24 25 26 27 28 29 ] . The findings of LOH and mutations of M6P/IGF2R in a wide variety of tumor types have led to the proposition that the M6P/IGF2R is a tumor suppressor gene.
Noticeably, the effect of ribozyme expression on cell growth was more apparent in the presence of IGF-II.
5 ng/ml) with or without excess unlabeled IGF-II (2 μg/ml).
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