Words similar to igf-ir
Example sentences for: igf-ir
How can you use “igf-ir” in a sentence? Here are some example sentences to help you improve your vocabulary:
The results obtained with the dominant negative IGF-IR are identical to published results reintroducing PTEN, hence, inhibition of upstream PI-3Kinase signaling might be a useful approach for PTEN-deficient tumors.
To test initially whether the PTEN-deficient U87 glioma cells might be susceptible to inhibition of the IGF-IR, we measured colony formation and tumor growth in the presence of an inhibitory antibody to the human IGF-IR (αIR3).
WT-infected cells gave the largest tumors in both experiments demonstrating that overexpression of the IGF-IR in a malignant cell can enhance tumor formation as we observed for the CHO cells.
IGF-I produces a chemotactic response in human melanoma cells and antisense to the IGF-IR mRNA prevents metastasis in the murine carcinoma cell H-59.
However, expression of the wild-type IGF-IR accelerated tumor growth and tumors were larger at sacrifice.