Words similar to hyal-

Example sentences for: hyal-

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Hyal-1 is a candidate tumor suppressor [ 5 18 ] , although it enhances extravasation and metastasis of prostate cancer cells [ 3 ] . Also, mutations in Hyal-1 may contribute to the pathogenesis of a lysosomal disorder, mucopolysaccharidosis IX [ 19 ] . Hyal-2 is a lysosomal protein, which is active at low pH [ 20 ] . This protein is also known to be a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus [ 21 ] .
Whether TGF-β1-induced antiapoptotic proteins such as TIAF1 and TIF2 inhibit the function of Hyal-1 and Hyal-2 remains to be determined.
TNF rapidly induces phosphorylation of IκBα, which normally peaks at 5-10 min, followed by proteasome-dependent degradation (10-20 min) [ 10 24 ] . IκBα degradation and NF-κB activation occurred, as determined 20 min after exposure of control and Hyal-1 cells to TNF.
Overexpressed Hyal-1 and Hyal-2 induced the expression of proapoptotic WOX1, but not p53, suggesting a role of WOX1 in the increased cellular susceptibility to TNF cytotoxicity.
Whether Hyal-2 causes mitochondrial membrane damage is unknown.