Example sentences for: hyal-

How can you use “hyal-” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • To determine whether TGF-β1 blocked Hyal-1 and Hyal-2-increased TNF killing, the cells were pretreated with TGF-β1 for 2 hr and then exposed to TNF-α in the continued presence of TGF-β1 for 16-24 hr.

  • Overexpressed Hyal-1 and Hyal-2 induced the expression of proapoptotic WOX1, but not p53, suggesting a role of WOX1 in the increased cellular susceptibility to TNF cytotoxicity.

  • Hyal-2-increased TNF susceptibility in L929 cells appears to be associated with 1) Hyal-2 upregulation of the proapoptotic WOX1, 2) Hyal-2 migration to the mitochondria during apoptotic cell death, and 3) the prolonged IκBα degradation and NF-κB activation in Hyal-2-expressing cells stimulated with TNF.

  • To further understand how Hyal-2 participates in the apoptosis pathway, the translocation of Hyal-2 to the mitochondria was examined during cell death.

  • In this study, experiments were designed to determine whether lysosomal Hyal-1 and Hyal-2 enhance TNF cytotoxic function and counteract TGF-β1-mediated TNF-resistance in L929 cells.


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