Words similar to hyaluronidases
Example sentences for: hyaluronidases
How can you use “hyaluronidases” in a sentence? Here are some example sentences to help you improve your vocabulary:
In situ hybridization demonstrated that the transcript is localized in the principal cells, confirming its epithelial location, similar to that reported for the mouse [ 11 12 ] . It must be stressed that because the probes used in the hybridization were generated from the unique 3' UTR of SPAM1 cDNA the possibility of cross-hybridization to paralogous hyaluronidases is highly unlikely.
In this study, the novel function of the lysosomal hyaluronidases Hyal-1 and Hyal-2 in increasing cellular sensitivity to TNF cytotoxicity is reported.
Hyaluronidases Hyal-1 and Hyal-2 play a critical role in cancer invasion and metastasis [ 3 4 5 ] , although inactivation of HYAL1 gene has been shown in head and neck squamous cell carcinomas [ 17 ] . Hyal-1, also known as Luca-1, is a lysosomal enzyme that is secreted from cells.
The Sperm Adhesion Molecule 1 (SPAM1 or PH-20) is a glycosyl-phosphatidylinositol (GPI)-linked protein found on all mammalian spermatozoa that have been examined, and has been reported to play multiple roles in fertilization [ 1 ] . Although a recent gene targeting study indicates that in mice, which have four active non-somatic hyaluronidases, Spam1 is not essential for fertilization [ 2 ] ; this is unlikely to be the case in humans where SPAM1 is the only such hyaluronidase present.
Unlike somatic ubiquitous hyaluronidases that are active only at acidic pH [ 8 ] , SPAM1 has hyaluronidase activity at both neutral and acidic pHs, which arise from two different regions within the hyaluronidase domain [ 4 ] . The neutral enzyme activity, which is predominant in insoluble membrane-bound SPAM1, is necessary for sperm to penetrate the hyaluronic acid (HA)-rich extracellular matrix of the cumulus cells surrounding the oocyte.
Loading...