Words similar to hyaluronidase
Example sentences for: hyaluronidase
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Variations in glycosylation patterns have been shown to exist among tissues [ 31 ] and glycosylation levels have been reported to influence hyaluronidase activity of SPAM1 in the mouse and horse [ 10 32 ] . Note that in the mouse, tissue differences in glycosylation patterns have been reported for the testis and epididymis [ 33 ] . It is possible that in the epididymis and vas deferens instead of hyaluronidase activity, a more important role of SPAM1 (which is a glycosidase) may be to modify surface proteins of sperm during their maturation.
Cumulus cells were removed by vortexing with 0.1% (w:v) hyaluronidase and denuded oocytes were transferred into 100 μl of Hepes-buffered TCM-199 supplemented with 7.5 μg/ml cytochalasin B (Sigma) and 10% FCS with the osmolarity adjusted to 300 mOsm by adding sorbitol (manipulation medium) at 29 or 42 h after IVM.
These observations are consistent with our previous finding that exogenous bovine testicular hyaluronidase PH-20 enhances TNF cytotoxicity in various cancer cells, and that TGF-β1 blocks the increased TNF cytotoxicity [ 8 15 ] . As summarized in the Figure 8, the underlying mechanisms whereby Hyal-2 induces TNF cytotoxicity appear to be associated with 1) Hyal-2 induction of the proapoptotic WOX1, 2) Hyal-2 migration to the mitochondria during apoptosis, and 3) the prolonged period of IκBα degradation and NF-κB activation in TNF-treated Hyal-2-expressing cells.
The Sperm Adhesion Molecule 1 (SPAM1 or PH-20) is a glycosyl-phosphatidylinositol (GPI)-linked protein found on all mammalian spermatozoa that have been examined, and has been reported to play multiple roles in fertilization [ 1 ] . Although a recent gene targeting study indicates that in mice, which have four active non-somatic hyaluronidases, Spam1 is not essential for fertilization [ 2 ] ; this is unlikely to be the case in humans where SPAM1 is the only such hyaluronidase present.
Immunohistochemical staining was performed using an indirect immunoperoxidase detection protocol (Vectastain Elite kit; Vector Laboratories) following treatment of sections with hyaluronidase to improve antibody penetration.
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