Words similar to hyaluronidase

Example sentences for: hyaluronidase

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The full-length murine hyaluronidase Hyal1 and Hyal2 cDNAs were found in the EST database (GenBank accession AA688635 and BF139787, respectively) and the determined DNA sequences have been deposited in the GenBank ( Hyal1 , AF422176; Hyal2 , AF422177).
In primates SPAM1 has been shown to play a role in three functions during fertilization: (1) hyaluronidase enzyme activity necessary for penetrating the cumulus [ 3 ] and for which it is best known [ 4 ] , (2) zona pellucida binding [ 3 ] , and (3) Ca 2+signaling-associated acrosomal exocytosis [ 5 6 7 ] .
Unlike somatic ubiquitous hyaluronidases that are active only at acidic pH [ 8 ] , SPAM1 has hyaluronidase activity at both neutral and acidic pHs, which arise from two different regions within the hyaluronidase domain [ 4 ] . The neutral enzyme activity, which is predominant in insoluble membrane-bound SPAM1, is necessary for sperm to penetrate the hyaluronic acid (HA)-rich extracellular matrix of the cumulus cells surrounding the oocyte.
Epididymal SPAM1 Demonstrates Hyaluronidase Activity
Testicular hyaluronidase PH-20 counteracts TGF-β1-induced TNF-resistance in L929 cells [ 8 ] . The goal of the present study was to examine whether lysosomal Hyal-1 and Hyal-2 enhance TNF cytotoxic function and counteract TGF-β1-mediated TNF-resistance in L929 cells.