Words similar to hyaluronidase
Example sentences for: hyaluronidase
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These observations are consistent with our previous finding that exogenous bovine testicular hyaluronidase PH-20 enhances TNF cytotoxicity in various cancer cells, and that TGF-β1 blocks the increased TNF cytotoxicity [ 8 15 ] . As summarized in the Figure 8, the underlying mechanisms whereby Hyal-2 induces TNF cytotoxicity appear to be associated with 1) Hyal-2 induction of the proapoptotic WOX1, 2) Hyal-2 migration to the mitochondria during apoptosis, and 3) the prolonged period of IκBα degradation and NF-κB activation in TNF-treated Hyal-2-expressing cells.
Cumulus cells were removed by treating eggs for 3 min with 1 mg/ml hyaluronidase (Sigma, St. Louis, MO) in M199; eggs were washed through four 50-ml drops of M199 medium covered with mineral oil using a pulled , heat-polished, Pasteur pipette (employed in all experiments).
It should also be noted that a study of the glycosylation and 2D-gel patterns of Spam1 from the epididymis and testis of mice indicates that epididymal Spam1 may be a unique isoform rather than a redundant protein [ 33 ] . Such a unique isoform may play a specific role in sperm maturation in humans where SPAM1 is the only reproductive hyaluronidase in the cluster on 7q31.
Interestingly, malignant and metastatic breast and prostate cancer cells frequently overexpress both hyaluronidase and TGF-β proteins [ 3 4 5 6 7 ] . Previously we have shown that bovine testicular hyaluronidase, also known as PH-20, increases the susceptibility of various cancer cells to tumor necrosis factor (TNF or TNF-α) cytotoxicity [ [ 8 ] , review].
Unlike somatic ubiquitous hyaluronidases that are active only at acidic pH [ 8 ] , SPAM1 has hyaluronidase activity at both neutral and acidic pHs, which arise from two different regions within the hyaluronidase domain [ 4 ] . The neutral enzyme activity, which is predominant in insoluble membrane-bound SPAM1, is necessary for sperm to penetrate the hyaluronic acid (HA)-rich extracellular matrix of the cumulus cells surrounding the oocyte.
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