Words similar to hsv
Example sentences for: hsv
How can you use “hsv” in a sentence? Here are some example sentences to help you improve your vocabulary:
Plasmid pVP16-mRXR encodes a fusion protein between the transcriptional transactivator VP16 from Herpes simplex virus (HSV) and the mouse RXR protein.
Drug-independent mutation frequency using non-HSV DNA
In this study, we have extended the findings of previous work [ 13 ] by using pol -recombinant viruses to examine mutation frequency in HSV.
This mutation has also been detected in clinical isolates from patients immunocompromised [ 12 ] or with AIDS [ 19 ] as well as resistant HSV selected in tissue culture [ 15 18 ] . Interestingly, this mutation was present in ACV rclinical isolates obtained during reactivation in the absence of drug pressure, as well as in ACV rstrains which evolved during ACV therapy and were followed by ACV-susceptible isolates at the next reactivation [ 19 ] .
The natural phenomenon of spontaneous mutation, which occurs in the absence of drug selection, results in the accumulation of approximately six to eight TK-deficient variants per 10 4plaque-forming viruses in virus populations that have never been exposed to selective pressure [ 6 10 12 ] . Furthermore, HSV-2 clinical isolates were shown to have a higher frequency of spontaneous mutations resistant to ACV and PCV, approximately 30-fold, compared to HSV-1 isolates, and the majority of these mutations are in tk . Consistent with this observation, HSV-2 strains also exhibited approximately a 20- to 80-fold higher spontaneous mutation rate to cidofovir (HPMPC), an inhibitor of HSV Pol, resistance compared with HSV-1 [ 21 ] . Therefore, these naturally-occuring mutations are not unique to tk and TK substrates as detected with antiviral agents ACV and PCV, but were extended with the direct Pol inhibitor, HPMPC, to other loci, most likely pol .
Loading...