Words similar to hsv
Example sentences for: hsv
How can you use “hsv” in a sentence? Here are some example sentences to help you improve your vocabulary:
The tk mutagenesis assay has been utilized by ourselves and others [ 10 13 ] to determine both frequency and spectrum of mutations in the HSV tk gene following selection for drug resistance.
The natural phenomenon of spontaneous mutation, which occurs in the absence of drug selection, results in the accumulation of approximately six to eight TK-deficient variants per 10 4plaque-forming viruses in virus populations that have never been exposed to selective pressure [ 6 10 12 ] . Furthermore, HSV-2 clinical isolates were shown to have a higher frequency of spontaneous mutations resistant to ACV and PCV, approximately 30-fold, compared to HSV-1 isolates, and the majority of these mutations are in tk . Consistent with this observation, HSV-2 strains also exhibited approximately a 20- to 80-fold higher spontaneous mutation rate to cidofovir (HPMPC), an inhibitor of HSV Pol, resistance compared with HSV-1 [ 21 ] . Therefore, these naturally-occuring mutations are not unique to tk and TK substrates as detected with antiviral agents ACV and PCV, but were extended with the direct Pol inhibitor, HPMPC, to other loci, most likely pol .
Specifically, this study evaluated the contribution of type 2 polymerase to mutation frequency when measured by the tk mutagenesis and non-HSV DNA mutagenesis assays.
Viral populations are naturally heterogeneous; there are approximately 6 to 8 TK deficient variants per 10 4plaque-forming units (PFU) of HSV-1 (laboratory strains and clinical isolates) that have never been exposed to antiviral selection [ 6 13 15 17 ] . Resistance to nucleoside inhibitors of HSV arises readily in tissue culture probably by selection of pre-existing mutants [ 10 13 18 ] . Moreover, Field et al.
The targeting vector also contains the HSV TK gene to allow for negative selection of non-recombinants.
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