Words similar to hsc
Example sentences for: hsc
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Numerous transcripts were up-regulated in conceptuses of filamentous morphology including, pro-interleukin-1β, interleukin-1β (IL-1β), s-adenosylhomocysteine hydrolase (SAHH), heat shock cognate 70 kDa protein (HSC70), metallopanstimulin-1 (MPS-1) and elfin.
The adenylate cyclase and associated proteins mentioned above, along with Hsp82p and Hsc82p, activate the cAMP pathway [ 19 ] , a pathway that acts in parallel with the MAPK pathway to promote filamentation.
Members of the HSP70 family have also been proposed to be involved with HSP90 chaperones regulating signal transduction pathways [ 32 ] . Unlike HSP70, HSC70 does not exhibit increased gene expression when exposed to heat stress or other agents such as sodium arsenate in the gastrula and neurula Xenopus embryo [ 33 ] . Tsang [ 34 ] suggested because of their ability to bind and transport folded and un-folded cellular proteins, HSP70 family members may function as a cross-linker to couple cellular proteins to the cytoskeletal matrix.
HSC70 gene expression was also significantly enhanced (P < 0.001) in filamentous conceptuses (Table 4), which displayed an approximate 10-fold increase in gene expression compared to spherical, ovoid and tubular morphologies (Figure 2).
The chaperon proteins such as Hsc73 could be involved in unfolding the substrates for them to fit into the degradation chamber and the final maturation of 20S proteasome from the 16S assembly intermediates could trap the substrates, such as Ump1 and Smads, inside the degradation chamber.