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Example sentences for: hsa
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Primarily examined through the use of G-banding cytogenetic techniques, the human and common chimpanzee karyotypes differ by only 10 euchromatic rearrangements: a telomere fusion between PTR chromosomes 12 and 13, resulting in HSA chromosome 2, and 9 pericentric inversions (HSA 1, 4, 5, 9, 12, 15, 16, 17, 18) [ 1 2 ] . The predominance of pericentric inversions between chimps and humans highlights their potential importance in the divergence of human from non-human primate species, and provides an opportunity to investigate the mechanism facilitating these rearrangements.
Thus, the ABCG5 and ABCG8 genes fit into a group of genes that are syntenic both in HSA2 and in RNO6.
A conserved segment between HSA2, RNO6, and MMU17 on RNO6q11-q16 has been demonstrated by Zoo-FISH analysis and gene mapping data, confirming this synteny [ 30 31 32 ] .
We then defined the inversion breakpoint interval as the region between the most distal probe on HSA 15q to display a PTR XVp signal, RP11-360J18 and the most proximal probe on HSA 15q to display a PTR XVq signal, RP11-736I24 (Figure 3).
The karyotypes of humans and the African and Asian great apes are remarkably well conserved, with relatively few large-scale chromosomal changes among these species despite the considerable phenotypic and biological differences between hominoids [ 1 2 3 ] . This conservation is particularly relevant in comparisons between the human ( Homo sapiens ; HSA) and common chimpanzee ( Pan troglodytes ; PTR) genomes, for in order to completely ascertain the evolution of our own lineage it is necessary to understand what differentiates us at the genomic level from our closest relatives.
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