Words similar to hsn

Example sentences for: hsn

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6B, panels 1 & 2) and co-localization of Smad1 and HsN3 was detected in the nucleus (Fig.
This interaction was suggested to play a role in Tax-induced proteasomal processing of the P105 subunit of NF-κB [ 32 ] . Other proteasome integral components, especially those in the 19S regulator of the 26S proteasome, have also been shown to bring proteins to proteasome for degradation [ 21 ] . Here we identified a unique role of HsN3 in the Az-involved targeting pathway that is coupled to BMP type I receptor activation.
Since the N-terminal prosequence of HsN3 is processed upon assembly into the 20S proteasome, we deleted the prosequence of HsN3 and replaced it with the Flag/T7-epitopes to assure that the epitopes will not be lost due to prosequence-processing.
In the absence of the co-expressed HsN3, Smad1 was co-precipitated with Az (Fig.
In a separate study, we have shown that Az and HsN3 play targeting roles in the proteasomal degradation of Smad1 upon the activation of BMP type I receptors [ 39 ] . The observed proteasomal degradation of Smad1 upon the activation of BMP signaling could simply serve to irreversibly terminate Smad1-mediated signaling pathways of BMPs.