Words similar to hpr

Example sentences for: hpr

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The mean weights of the rats in the various experimental groups differed by less than 10% from those of rats not treated with a chemopreventive agent, except for the rats treated with a combination of tamoxifen and 4-HPR, in which the mean weight was approximately 15% lower than the that in untreated group by the end of the study (Fig.
In this regard, this demonstration that the expression of TGF-βs in the preclinical rat model is unaffected by tamoxifen, 9cRA, or 4-HPR may actually have positive implications, because all three agents are already in clinical use.
In the present study, we used a carcinogen-induced rat model of mammary carcinogenesis to test whether chemoprevention by tamoxifen and by two different retinoids (4-HPR, also known as fenretinide; and 9-cRA) is associated with local upregulation of TGF-βs in the initiated mammary gland.
Expression plasmids for hGR, hPR α and ER have been also described [ 29 30 ] . Wild-type inactive form of Stat3 (pCAGGS-HA-Stat3) was from Dr. T. Hirano, Osaka University, Japan [ 32 ] . The plasmid expressing a constitutively active form of Stat3 (Stat3C-Flag) was obtained from Dr. J. Darnell, jr.
4-HPR alone had a relatively modest effect on tumor incidence in the present study.