Words similar to hpop
Example sentences for: hpop
How can you use “hpop” in a sentence? Here are some example sentences to help you improve your vocabulary:
Indeed, both human homologs of yPOP2, hCAF1 and hPOP2, lack the 148 N-terminal amino acids which are, in yPOP2, required for transcriptional activation, whereas the yPOP2 C-terminus, which is involved in the interaction with yCCR4, is conserved in hCAF1 [ 11 ] and hPOP2 [ 19 ] . Similarly, hNOT2, the human homolog of the yNOT2 component of the CCR4-NOT complex, harbors a N-terminal domain divergent from that of yNOT2 -required for transcriptional activation and interaction with the yeast ADA2 factor-, but has conserved the C-terminal domain which is absolutely required for the yCCR4-associated function of yNOT2 [ 19 20 ] . Therefore, it looks as if genes of the CCR4-NOT complex have undergone a "concerted" phylogenetic evolution, with the yeast genes encoding multifunctional proteins and the animal genes only encoding "specialized" proteins specific for the CCR4-NOT complex.
Hence, the present identification of the human ortholog of yCCR4 and the demonstration that it binds to hPOP2 now provide an additionnal piece of the puzzle, strongly suggesting the existence of a CCR4-NOT complex in humans.
Two homologs of yPOP2 have been identified in mammals: the mouse/human CAF1 [ 11 16 17 33 ] and, more recently, the human homolog named hPOP2 or hCALIF [ 18 19 ] . Both mCAF1 [ 11 ] and hPOP2 [ 19 ] interact with yCCR4, and the yCCR4 LRR is essential for these interactions.
The pVP16-hCAF1 and pVP16-hPOP2 constructs were obtained upon insertion of the hCAF1 and hPOP2 coding regions into the pSG5FNV vector, in-frame with the VP16 transactivation domain coding sequence, as previously described [ 17 25 ] .
A vector expressing hCAF1 (pVP16-hCAFl) or hPOP2 (pVP16-hPOP2) fused to the VP16 activation domain was also produced (Fig.
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