Words similar to hpop

Example sentences for: hpop

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Third, the ability of yCCR4 to bind mCAF1 and hPOP2 is conserved for the mammalian protein, since we could demonstrate, using two-hybrid assays and far-Western blot analyses, an in vivo and in vitro interaction between hCCR4 and hCAF1 or hPOP2/CALIF.
To determine whether yCCR4-yPOP2 interactions are evolutionarily conserved, we examined whether hCCR4 can bind hCAF1 and hPOP2 in a two-hybrid assay in mammalian cells.
Two homologs of yPOP2 have been identified in mammals: the mouse/human CAF1 [ 11 16 17 33 ] and, more recently, the human homolog named hPOP2 or hCALIF [ 18 19 ] . Both mCAF1 [ 11 ] and hPOP2 [ 19 ] interact with yCCR4, and the yCCR4 LRR is essential for these interactions.
4), thus indicating that m.nocturnin does not interact with hCAF1 or hPOP2, as expected from the absence of an LRR domain in this protein.
Hence, the present identification of the human ortholog of yCCR4 and the demonstration that it binds to hPOP2 now provide an additionnal piece of the puzzle, strongly suggesting the existence of a CCR4-NOT complex in humans.