Example sentences for: hepatitis

How can you use “hepatitis” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Infection with the hepatitis C virus (HCV) occurs primarily through percutaneous exposure to contaminated blood or blood products.

  • Amodiaquine is still used to treat malaria, but was withdrawn from general use for malaria prophylaxis in 1986 after it was found to cause liver damage and hepatitis, mostly anicteric.

  • Sulfasalazine (SSZ) is a widely used and highly effective anti-inflammatory agent in the treatment of Crohn's disease and ulcerative colitis [ 1 2 3 ] . SSZ is also being used with increasing frequency in the treatment of various rheumatolgical disorders [ 4 5 6 7 ] . SSZ is preferred over other agents such as gold and penicillamine in rheumatology patients due to its more favorable side effect profile [ 8 9 10 ] . Nonetheless, rash, fever, and dyspepsia occur in 3% to 20% of treated patients [ 7 11 12 ] . These reactions are usually dose dependent and improve with dose reduction or discontinuation [ 7 12 ] . However, more serious but less common side effects have also been reported [ 13 14 15 16 17 18 19 ] . We now report a severe systemic reaction to SSZ in a 21-year-old female with rheumatoid arthritis characterized by granulomatous infiltration of the bone marrow, colon and small bowel as well as cholestatic hepatitis and seizures.

  • Other obvious targets for selection mapping are the hepatitis C and foot-and-mouth disease viruses.

  • Both severe hepatitis and acute liver failure have been attributed to SSZ [ 25 26 27 28 ] . Patients with SSZ hepatotoxicity demonstrate a prompt recurrence of symptoms upon rechallenge with SSZ or sulfonamide [ 15 29 30 31 ] . Susceptibility to the toxic effects of SSZ and other sulfonamides may be due to the interaction of metabolic pathways regulating N-acetylation and specific detoxification of the metabolites of the drug [ 32 33 ] . However, it remains unclear if genetic differences in drug metabolizing enzyme expression may increase the risk of SSZ toxicity.


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