Words similar to hct

Example sentences for: hct

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By counteracting Cdk1-mediated phosphorylations, Cdc14 activates both Hct1/Cdh1, which targets Clb2 for degradation [ 3 4 5 ] , and Swi5, which turns on the transcription of Cdk1 inhibitor Sic1 [ 6 3 ] . Degradation of Clb2 and accumulation of Sic1 act in concert to eliminate mitotic Cdk activity, which is required for exit from mitosis [ 7 ] . Thus, elucidating how Cdc14 is regulated holds the key to understanding how cells exit mitosis.
Whereas all tab mutants tested were able to bypass cdc15Δ in the absence of HCT1 and two ( net1 tab 2-1and CDC14 TAB 6-1) were able to bypass cdc15Δ in the absence of either SIC1 or HCT1, four tab mutants ( tab1-1, tab3-1, TAB5-1, and TAB7-1 ) failed to bypass in the absence of SIC1 (Table 3).
In S. cerevisiae, a key event accompanying exit from mitosis is the inactivation of Clb/Cdc28 protein kinase achieved through degradation of Clb and accumulation of the Clb/Cdc28 inhibitor Sic1 (reviewed in [ 1 ] ). Anaphase-Promoting Complex/Cyclosome (APC/C) ubiquitin ligase and its substrate specific activator Hct1/Cdh1 are required for degradation of Clb2, the major mitotic cyclin in the budding yeast (reviewed in [ 2 ] ). Whereas hct1Δ and sic1Δ cells appear relatively normal,
Stein et al [ 29] have found that cytokines such as interleukin-2, interferon-γ and tumour necrosis factor-α were capable of decreasing the expression of MDR1 mRNA in the colon carcinoma cell lines HCT15 and HCT16.