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Example sentences for: hct
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In S. cerevisiae, a key event accompanying exit from mitosis is the inactivation of Clb/Cdc28 protein kinase achieved through degradation of Clb and accumulation of the Clb/Cdc28 inhibitor Sic1 (reviewed in [ 1 ] ). Anaphase-Promoting Complex/Cyclosome (APC/C) ubiquitin ligase and its substrate specific activator Hct1/Cdh1 are required for degradation of Clb2, the major mitotic cyclin in the budding yeast (reviewed in [ 2 ] ). Whereas hct1Δ and sic1Δ cells appear relatively normal,
To assay if SIC 1 or HCT1 was required for the Tab +phenotype of tab mutants, SIC1 or HCT1 was replaced by his5 +in cdc15Δ::TRP1 tab [pMET3-CDC15, URA3 ] strains.
Velocity elevation corresponding to increased cerebral blood flow in all patients with anemia has been noted, with an approximate linear increase in velocity for decrease in Hb or HCT [ 12 ] . There are also data to suggest that patients with Hb SS have higher flow velocities than those with normal Hb A at comparable levels of anemia, suggesting the amount and composition of the Hb are both involved in the velocity elevation of sickle cell disease [ 13 ] .
hct1Δ sic1Δ cells are inviable, presumably due to their inability to extinguish Cdc28 activity in telophase [ 3 ] .
Whereas all tab mutants tested were able to bypass cdc15Δ in the absence of HCT1 and two ( net1 tab 2-1and CDC14 TAB 6-1) were able to bypass cdc15Δ in the absence of either SIC1 or HCT1, four tab mutants ( tab1-1, tab3-1, TAB5-1, and TAB7-1 ) failed to bypass in the absence of SIC1 (Table 3).
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