Words similar to hct
Example sentences for: hct
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In S. cerevisiae, a key event accompanying exit from mitosis is the inactivation of Clb/Cdc28 protein kinase achieved through degradation of Clb and accumulation of the Clb/Cdc28 inhibitor Sic1 (reviewed in [ 1 ] ). Anaphase-Promoting Complex/Cyclosome (APC/C) ubiquitin ligase and its substrate specific activator Hct1/Cdh1 are required for degradation of Clb2, the major mitotic cyclin in the budding yeast (reviewed in [ 2 ] ). Whereas hct1Δ and sic1Δ cells appear relatively normal,
Velocity elevation corresponding to increased cerebral blood flow in all patients with anemia has been noted, with an approximate linear increase in velocity for decrease in Hb or HCT [ 12 ] . There are also data to suggest that patients with Hb SS have higher flow velocities than those with normal Hb A at comparable levels of anemia, suggesting the amount and composition of the Hb are both involved in the velocity elevation of sickle cell disease [ 13 ] .
After addition of 50 μ l 125I-hCT, and 200 μ l gelatin buffer, incubation was continued for 2 days.
Whereas all tab mutants tested were able to bypass cdc15Δ in the absence of HCT1 and two ( net1 tab 2-1and CDC14 TAB 6-1) were able to bypass cdc15Δ in the absence of either SIC1 or HCT1, four tab mutants ( tab1-1, tab3-1, TAB5-1, and TAB7-1 ) failed to bypass in the absence of SIC1 (Table 3).
By counteracting Cdk1-mediated phosphorylations, Cdc14 activates both Hct1/Cdh1, which targets Clb2 for degradation [ 3 4 5 ] , and Swi5, which turns on the transcription of Cdk1 inhibitor Sic1 [ 6 3 ] . Degradation of Clb2 and accumulation of Sic1 act in concert to eliminate mitotic Cdk activity, which is required for exit from mitosis [ 7 ] . Thus, elucidating how Cdc14 is regulated holds the key to understanding how cells exit mitosis.
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