Words similar to herα
Example sentences for: herα
How can you use “herα” in a sentence? Here are some example sentences to help you improve your vocabulary:
We have previously investigated nmt55/p54 nrbprotein expression in human breast tumors and observed a statistically significant association between decreased nmt55/p54 nrbexpression, loss of hERα and hPR and increased tumor size [ 13 ] . It is possible that decreased nmt55/p54 nrbexpression represents poor tumor differentiation, increased tumor growth and metastases since reduced or absent hERα expression and function correlates with poor tumor differentiation [ 11 36 ] and tumor size is a strong indicator of tumor progression [ 37 ] . Here we investigated nmt55/p54 nrbmRNA expression using Northern blot analyses and ribonuclease protection assays to determine if the reduction of nmt55/p54 nrbprotein expression was the result of transcriptional regulation.
Tissue sections stained positively with monoclonal antibodies EVG F9 (Panel A) and 4.14 (Panel B) showing the expression of hERα and hPR, respectively.
Monoclonal antibodies NMT-1 and EVG F9 were developed to unique peptides encompassing amino acids 140-154 and 140-154-247-263 of hERα, respectively [ 21 22 23 24 ] . Monoclonal antibody 4.14 was raised against a peptide representing amino acid sequence 533-547 of human progesterone receptor (hPR) [ 25 ] . All other chemicals were reagent grade and were obtained from commercial sources.
Figure 7shows immunohistochemical analyses of a human breast tumor using hERα, hPR and nmt55/p54 nrbspecific antibodies.
Based on the data presented in Figures 2and 3, it appears that nmt55/p54 nrbmRNA is expressed independent of tumor hormonal status suggesting that nmt55/p54 nrbmRNA is not regulated by hERα.
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