Words similar to herα
Example sentences for: herα
How can you use “herα” in a sentence? Here are some example sentences to help you improve your vocabulary:
Monoclonal antibodies NMT-1 and EVG F9 were developed to unique peptides encompassing amino acids 140-154 and 140-154-247-263 of hERα, respectively [ 21 22 23 24 ] . Monoclonal antibody 4.14 was raised against a peptide representing amino acid sequence 533-547 of human progesterone receptor (hPR) [ 25 ] . All other chemicals were reagent grade and were obtained from commercial sources.
mRNA transcripts for nmt55/p54 nrbshowed similar expression in human breast tumors and were not related to hERα expression.
While these techniques measure either hERα content or its cellular distribution, they do not provide the means for assessing hERα functionality.
It has been proposed that loss of hERα expression in breast tumors is the result of aberrant RNA processing [ 40 41 42 43 ] . These aberrantly spliced mRNAs, if translated, could lead to truncated receptors with hormone binding but not DNA binding function [ 44 ] . Further, there is evidence for the role of RNA processing in oncogenesis [ 45 46 ] . Many studies, including those on human hnRNP A2/B1 and the CD44 gene, suggest that high fidelity pre-mRNA splicing is critical to normal cellular function and may play a key role in oncogenesis and breast cancer progression [ 47 48 ] . The strong association between nmt55/p54 nrband hERα expression indicates that nmt55/p54 nrbmay be an important marker for breast cancer progression.
This lack of response may be attributed, at least in part, to the presence of nonfunctional hERα as determined by the inability of hERα to bind hormone, to recognize and bind to specific DNA-responsive elements and/or its inability to recruit other transcriptional activation factors [ 6 11 12 ] . It may also be attributed to tumor heterogeneity in which some tumor cells may continue to express functional hERα while other cells may express either dysfunctional hERα or do not express hERα at all.
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