Words similar to herα
Example sentences for: herα
How can you use “herα” in a sentence? Here are some example sentences to help you improve your vocabulary:
Further studies are necessary to determine a functional link between this RNA binding protein and hERα in human breast cancer.
These data, along with our previous observations, suggest that the association of nmt55/p54 nrband hERα expression represents three separate human breast tumor phenotypes.
We have previously investigated nmt55/p54 nrbprotein expression in human breast tumors and observed a statistically significant association between decreased nmt55/p54 nrbexpression, loss of hERα and hPR and increased tumor size [ 13 ] . It is possible that decreased nmt55/p54 nrbexpression represents poor tumor differentiation, increased tumor growth and metastases since reduced or absent hERα expression and function correlates with poor tumor differentiation [ 11 36 ] and tumor size is a strong indicator of tumor progression [ 37 ] . Here we investigated nmt55/p54 nrbmRNA expression using Northern blot analyses and ribonuclease protection assays to determine if the reduction of nmt55/p54 nrbprotein expression was the result of transcriptional regulation.
This lack of response may be attributed, at least in part, to the presence of nonfunctional hERα as determined by the inability of hERα to bind hormone, to recognize and bind to specific DNA-responsive elements and/or its inability to recruit other transcriptional activation factors [ 6 11 12 ] . It may also be attributed to tumor heterogeneity in which some tumor cells may continue to express functional hERα while other cells may express either dysfunctional hERα or do not express hERα at all.
Figure 8represents a tumor which exhibited positive staining for hERα (Panel A), hPR (Panel B), and nmt55/p54 nrbwhen utilizing polyclonal antibody NMT-5 (Panel D).
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