Words similar to herα
Example sentences for: herα
How can you use “herα” in a sentence? Here are some example sentences to help you improve your vocabulary:
Figure 8represents a tumor which exhibited positive staining for hERα (Panel A), hPR (Panel B), and nmt55/p54 nrbwhen utilizing polyclonal antibody NMT-5 (Panel D).
We have previously investigated nmt55/p54 nrbprotein expression in human breast tumors and observed a statistically significant association between decreased nmt55/p54 nrbexpression, loss of hERα and hPR and increased tumor size [ 13 ] . It is possible that decreased nmt55/p54 nrbexpression represents poor tumor differentiation, increased tumor growth and metastases since reduced or absent hERα expression and function correlates with poor tumor differentiation [ 11 36 ] and tumor size is a strong indicator of tumor progression [ 37 ] . Here we investigated nmt55/p54 nrbmRNA expression using Northern blot analyses and ribonuclease protection assays to determine if the reduction of nmt55/p54 nrbprotein expression was the result of transcriptional regulation.
These data, along with our previous observations, suggest that the association of nmt55/p54 nrband hERα expression represents three separate human breast tumor phenotypes.
Tissue sections stained positively with monoclonal antibodies EVG F9 (Panel A) and 4.14 (Panel B) showing the expression of hERα and hPR, respectively.
The concentration of unoccupied hERα was determined by ligand binding analyses as described previously [ 22 27 28 29 30 ] . Briefly, cytosols were incubated with 5 nM [ 3H] E 2 in the absence (total binding) or presence (nonspecific binding) of a 1000-fold molar excess of unlabeled DES for 16-20 hours at 4°C.
Loading...