Words similar to herα
Example sentences for: herα
How can you use “herα” in a sentence? Here are some example sentences to help you improve your vocabulary:
Figure 8represents a tumor which exhibited positive staining for hERα (Panel A), hPR (Panel B), and nmt55/p54 nrbwhen utilizing polyclonal antibody NMT-5 (Panel D).
While these techniques measure either hERα content or its cellular distribution, they do not provide the means for assessing hERα functionality.
mRNA transcripts for nmt55/p54 nrbshowed similar expression in human breast tumors and were not related to hERα expression.
We have previously investigated nmt55/p54 nrbprotein expression in human breast tumors and observed a statistically significant association between decreased nmt55/p54 nrbexpression, loss of hERα and hPR and increased tumor size [ 13 ] . It is possible that decreased nmt55/p54 nrbexpression represents poor tumor differentiation, increased tumor growth and metastases since reduced or absent hERα expression and function correlates with poor tumor differentiation [ 11 36 ] and tumor size is a strong indicator of tumor progression [ 37 ] . Here we investigated nmt55/p54 nrbmRNA expression using Northern blot analyses and ribonuclease protection assays to determine if the reduction of nmt55/p54 nrbprotein expression was the result of transcriptional regulation.
Thus, hERα provides a useful prognostic index in patients with metastatic disease and is associated with disease-free survival [ 7 8 9 10 ] . However, 35% of all patients with hERα positive (ER+) tumors do not respond to hormonal interventions suggesting cellular and molecular alterations [ 6 11 12 ] .
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