Words similar to herα

Example sentences for: herα

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We have previously investigated nmt55/p54 nrbprotein expression in human breast tumors and observed a statistically significant association between decreased nmt55/p54 nrbexpression, loss of hERα and hPR and increased tumor size [ 13 ] . It is possible that decreased nmt55/p54 nrbexpression represents poor tumor differentiation, increased tumor growth and metastases since reduced or absent hERα expression and function correlates with poor tumor differentiation [ 11 36 ] and tumor size is a strong indicator of tumor progression [ 37 ] . Here we investigated nmt55/p54 nrbmRNA expression using Northern blot analyses and ribonuclease protection assays to determine if the reduction of nmt55/p54 nrbprotein expression was the result of transcriptional regulation.
The concentration of unoccupied hERα was determined by ligand binding analyses as described previously [ 22 27 28 29 30 ] . Briefly, cytosols were incubated with 5 nM [ 3H] E 2 in the absence (total binding) or presence (nonspecific binding) of a 1000-fold molar excess of unlabeled DES for 16-20 hours at 4°C.
Finally, the third phenotype represents tumors that do not express hERα and nmt55/p54 nrb.
While these techniques measure either hERα content or its cellular distribution, they do not provide the means for assessing hERα functionality.
Figure 8represents a tumor which exhibited positive staining for hERα (Panel A), hPR (Panel B), and nmt55/p54 nrbwhen utilizing polyclonal antibody NMT-5 (Panel D).