Example sentences for: gtpases

How can you use “gtpases” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Members of this family include RhoA, RhoB, RhoC (which are isoforms), Cdc42, G25K, RhoG, Rac1, Rac2, and TC10 (reviewed in [ 34 ] ). In fibroblast models, these GTPases have been proposed to act in a concerted hierarchy to coordinately regulate distinct morphological features.

  • The Rho family of GTPases is largely responsible for maintenance of cell shape in a variety of cell types, and this involves regulation of the actin cytoskeleton.

  • Further study of Rho and it's related GTPases and downstream effector molecules, will be important in elucidating mechanisms regulating the lymphocyte cytoskeleton and thus T cell function.

  • Hence, considerable diversity of protein domains appears to have emerged prior to the "crystallization" [ 95 ] of a transcription machinery similar to the one that operates in modern cells and probably had been already in place in LUCA [ 96 ] . Similar conclusions regarding the early stages of protein domain evolution have been reached previously as a result of evolutionary analysis of proteins involved in translation, such as aminoacyl-tRNA synthetases and GTPases: substantial diversification of protein domains had occurred prior to the "crystallization" of elaborate, modern-type translation machinery [ 66 97 ] .

  • Interestingly, inhibition of Rho-p160ROCK has recently been shown to give similar lymphocyte morphology as inhibition of Rho with C3 [ 50 ] . Another interesting candidate may be p120 PKN, as recent studies have established that PKN phosphorylates cytoskeletal intermediate filaments [ 47 ] and is directly linked to the cytoskeletal network through associations with α-actinin [ 48 ] . Also, PKN may be involved in relating cytoplasmic signals to the nucleus, for in response to stress, nuclear translocation of PKN occurs [ 49 ] . This is particularly important in light of previous work demonstrating that inactivation of Rho in peripheral blood T lymphocytes inhibits costimulatory signals up-regulating IL-2 production [ 25 ] . Future experiments will focus on determining the relationship of Rho GTPases and the regulation of T cell morphology [ 25 51 52 ] .


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