Words similar to gtpases

Example sentences for: gtpases

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Amino acid substitutions in the N(T)KxD motif cause a drastic reduction in the affinity of Ras-related GTPases for guanine nucleotides [ 35 36 ] . When overexpressed in cultured cells, these mutant GTPases function as dominant-suppressors of their endogenous counterparts [ 26 27 31 ] , presumably because they can compete for interaction with effectors, exchange factors or docking proteins, but cannot cycle on and off membranes in a nucleotide-dependent manner.
These include p150 RhoA-binding kinase α and β (p150 ROKα and β) [ 40 41 ] , p160 Rho-associated coiled-coil containing protein kinase (Rho-p160ROCK) [ 42 ] , p164 Rho kinase [ 43 ] , p120 protein kinase N (p120 PKN) [ 44 45 ] , and PKC-related kinase-2 (PRK-2) [ 46 ] . These kinases specifically bind to the GTP bound form of Rho, except for PRK-2, which can bind both Rho and Rac GTPases.
The second region where the sequence of Rab24 differs substantially from other Rab GTPases is the last 38 amino acids of the C-terminal tail.
These posttranslational lipid modifications are essential for attachment of the GTPases to the cytosolic face of intracellular vesicles and/or to the cytosolic leaflet of the plasma membrane, thereby specifying subcellular targets for GTPase action(s).
Isoprenylation serves to target the GTPases to the proper organelle membrane, where their actions often relate to cytoskeletal dynamics and/or vesicle trafficking [20,42].