Example sentences for: gtpases

How can you use “gtpases” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • FH proteins control rearrangements of the actin cytoskeleton and members of this family have been found to interact with Rho-GTPases.

  • In all of the known Ras-related GTPases the guanine nucleotide binding site is surrounded by a set of highly conserved sequence elements [ 33 34 ] . One of these elements, termed the G2 motif, consists of NKxD (with the asparagine located at position 116 in H-Ras).

  • This could occur by the release of limited effector molecules shared between the two GTPases, possibilities that are currently under investigation.

  • The functions of Boi1/Boi2 appear to be linked to those of Cdc42 and Rho3, which are Rho-type GTPases that are important for polarized cell growth [ 4 5 6 7 8 9 ] . Boi1 and Boi2 display two-hybrid interactions with both wild-type and mutationally activated Cdc42 but not with a mutant version of Cdc42 that is predicted to be impaired in the ability to bind nucleotide, suggesting that Boi1 and Boi2 may associate with the GTP-bound ("active") form of Cdc42 [ 1 ] . Further evidence that some function of Boi1 is linked to that of Cdc42 is that overexpression of Boi1 inhibits bud emergence and that this inhibition can be suppressed by overexpression of Cdc42 [ 1 2 ] . RHO3 can serve as a multicopy suppressor of the lethality caused by deletion of BOI1 and BOI2 [ 1 2 ] . These findings are consistent with the possibilities that Boi1 and Boi2 are targets of Cdc42 that promote cell growth in a manner that is regulated by Rho3.

  • PLD1 is an extracellular signal-activated phospholipase; its activity rises when receptors for certain hormones, growth factors, neurotransmitters, cytokines, and other mediators are activated, and upon treatment of cells with phorbol esters (reviewed in [ 7 8 ] ). Studies using recombinant PLD1 tagged with green fluorescent protein or Flu-epitopes indicate that it is localized in the endoplasmic reticulum, Golgi apparatus, late endosomes, and plasma membrane ( [ 6 ] , reviewed in [ 7 ] ). In vitro, basal PLD1 activity is usually low and can be stimulated by a variety of factors, including phosphatidylinositol 4, 5-bisphosphate (PIP 2 ), protein kinase C (PKC), and several small GTPases, e.g.


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