Words similar to gtpase-activating
Example sentences for: gtpase-activating
How can you use “gtpase-activating” in a sentence? Here are some example sentences to help you improve your vocabulary:
3G) interacts with G protein-coupled receptor kinases, and exhibits ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity.
Cdc5 also helps to activate the MEN by directly phosphorylating and disabling Bfa1 [ 29 ] , which is thought to inhibit Tem1 by serving as a GTPase-activating protein.
The Bub2/Bfa1 GTPase-activating protein (GAP) complex inhibits the MEN and cytokinesis in response to DNA damage and spindle misorientation ( [ 32 ] ; reviewed in [ 33 ] ). bub2Δ and CDC14 TAB 6-1cells show similar chromosome instability as wild-type cells.
Our model does differ in several respects from the canonical pheromone response pathway depicted in Fig 1. It includes more members of the heterotrimeric G protein complex, including the alpha, beta, and gamma subunits, the GDP-GTP exchange factor, and the GTPase-activating protein (Gpa1p, Ste4p, Ste18p, Cdc24p, and Sst2p, respectively).
Tem1 is thought to be kept inactive throughout early mitosis by the two-component GTPase-activating protein complex Bub2/Bfa1 which co-localizes with Tem1 at the spindle pole body [ 10 11 ] . When the mitotic spindle penetrates the mother-daughter neck, the Tem1-bound spindle pole body is translocated into the daughter cell where a cortical pool of Lte1 is thought to activate Tem1 [ 12 13 ] . In addition to this spatial regulation, the GTPase activity of Bfa1 is thought to be inactivated through its phosphorylation by Cdc5 [ 14 ] , but it remains unknown how this process is coordinated with the presumed juxtaposition of Lte1 and Tem1 in the daughter cell.
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