Example sentences for: glycosaminoglycan

How can you use “glycosaminoglycan” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • However, TGF-β1 expression also induced significant pathology in the rabbit knee as well as in the adjacent muscle, including stimulation of glycosaminoglycan (GAG) release and nitric oxide synthesis, and enhancement of fibrogenesis and muscle edema.

  • PEDF, pigment epithelium-derived factor; GAG, glycosaminoglycan; HS, heparan sulfate; CM, media conditioned by retinoblastoma cells.

  • With regard to the repair phase, following IL-1-induced cartilage damage, relatively little is known, but partial to complete recovery appears possible [ 1 3 ] . In studies of repair, investigators focused on glycosaminoglycan (GAG) - an important and abundant cartilage macromolecule - and used histologic, biochemical, and/or radiolabel incorporation methods to measure GAG concentration ([GAG]) and/or GAG synthesis rates at selected time points.

  • Regional analysis of glycosaminoglycan concentration recovery

  • Aggrecan and versican are aggregating proteoglycans that are key constituents found in the extracellular matrix [ 41 ] . Both proteoglycans contain amino-terminal hyaluronic acid-binding regions, central core glycosaminoglycan attachment domains, and carboxyl-terminal domains containing EGF-like modules (one in aggrecan and two in versican), C-type lectin like modules and complement regulatory protein-like modules [ 49 50 ] . Fibulin-1 exhibits calcium-dependent binding to the carboxyl-terminal domain of aggrecan and versican [ 41 ] . The binding site of aggrecan to fibulin-1 maps to the type II EGF-like modules 8-9 and the carboxyl-terminal domain of fibulin-1 [ 41 ] . The binding site of versican to fibulin-1 maps to the type II EGF-like modules 2-8 of fibulin-1 [ 41 ] .


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