Words similar to glycyrrhetinic
Example sentences for: glycyrrhetinic
How can you use “glycyrrhetinic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Glycyrrhetinic acid is an aglycone saponin extracted from licorice root [ 7 ] and saponines have hypnotic effects [ 17 ] . Carbenoxolone is also the succinyl ester of glycyrrhetinic acid.
Carbenoxolone, the succinyl ester of glycyrrhetinic acid [ 1 ] , is now used in clinical treatment of ulcer diseases [ 2 ] . It has some pharmacological properties such as: the inhibition of 11β-hydroxy steroid dehydrogenase (11β-HSD) [ 1 ] , and inhibition of gap junctional intercellular communication [ 3 ] . Electrotonic synaptic communication between neurons via gap junctions (GJs) is increasingly recognized as an important synchronizing mechanism in the brain.
Less is known about the effects of carbenoxolone on GJs, although it has been proposed that glycyrrhetinic acid, to which carbenoxolone is related, binds directly to connexin molecules causing a conformational change leading to a closure of the junction [ 7 ] . Modeling studies indicate that neuronal synchronization can be mediated by low densities of GJs either between dendrites, as long as these dendrites are excitable [ 10 ] , or between the axons of pyramidal cells [ 11 ] . Furthermore, the electrotonic coupling could be promoted during epileptogenesis [ 12 13 ] .
As a matter of fact it was suggested that the gap junction coupling state between neurons in SCN is not static but dynamically regulated by the GABA A receptor system [ 14 ] . Also in vitro guinea-pig brain preparation prolonged seizure-like activity elicited using a brief application of bicuculline was abolished by the GJ channel blockers octanol and glycyrrhetinic acid as well as by intracellular acidification [ 16 ] .
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