Words similar to glycyrrhetinic
Example sentences for: glycyrrhetinic
How can you use “glycyrrhetinic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Less is known about the effects of carbenoxolone on GJs, although it has been proposed that glycyrrhetinic acid, to which carbenoxolone is related, binds directly to connexin molecules causing a conformational change leading to a closure of the junction [ 7 ] . Modeling studies indicate that neuronal synchronization can be mediated by low densities of GJs either between dendrites, as long as these dendrites are excitable [ 10 ] , or between the axons of pyramidal cells [ 11 ] . Furthermore, the electrotonic coupling could be promoted during epileptogenesis [ 12 13 ] .
Carbenoxolone, the succinyl ester of glycyrrhetinic acid [ 1 ] , is now used in clinical treatment of ulcer diseases [ 2 ] . It has some pharmacological properties such as: the inhibition of 11β-hydroxy steroid dehydrogenase (11β-HSD) [ 1 ] , and inhibition of gap junctional intercellular communication [ 3 ] . Electrotonic synaptic communication between neurons via gap junctions (GJs) is increasingly recognized as an important synchronizing mechanism in the brain.
As a matter of fact it was suggested that the gap junction coupling state between neurons in SCN is not static but dynamically regulated by the GABA A receptor system [ 14 ] . Also in vitro guinea-pig brain preparation prolonged seizure-like activity elicited using a brief application of bicuculline was abolished by the GJ channel blockers octanol and glycyrrhetinic acid as well as by intracellular acidification [ 16 ] .
Glycyrrhetinic acid is an aglycone saponin extracted from licorice root [ 7 ] and saponines have hypnotic effects [ 17 ] . Carbenoxolone is also the succinyl ester of glycyrrhetinic acid.
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