Words similar to glypican

Example sentences for: glypican

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Human Glypican5: GPC5
For the present study we have selected two candidate genes viz. human peptide transporter (SLC15A1) and human glypican5 (GPC5) for mutation screening from this region.
Deletion of the 13q region is associated with human 13q syndrome, a developmental disorder [ 24 ] . Some of the proteoglycans play important functional roles in neurogenesis, axon guidance, synapse development [ 25 ] , and cellular growth and differentiation [ 26 27 23 ] . Mutations in GPC3 cause Simpson-Golabi-Behmel syndrome [ 28 29 ] , however, no mutations were detected in the GPC5 and GPC6 genes [ 30 ] . The glypican1 gene has been suggested to be a good candidate for brachydactyly type E [ 31 ] . Given that, GPC5 is highly expressed in brain and mutations in other genes of the glypican families are associated with developmental disorder; GPC5 could be a potential candidate gene for Bipolar disorder.
Mutation screening of the glypican genes in these patients might give clue to Schizophrenia susceptibility locus.
Glypican5 is structurally correlated to glypican3 and localized to chromosome 13q32.