Words similar to glypican

Example sentences for: glypican

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Several disorders have been reported due to mutations in glypican gene families [ 31 37 ] and interestingly due to deletion of region on chr.
GPC5 belongs to the cell surface heparan sulfate proteoglycan family and is expressed in limb, kidney, developing central nervous system and brain tissue [ 21 22 ] . In vertebrates 6 glypican family members belonging to the proteoglycan family have so far been characterized [ 23 ] . Although there is a high degree of conservation of polypeptide sequence among family members, they are localized to different chromosomes.
Mutation screening of the glypican genes in these patients might give clue to Schizophrenia susceptibility locus.
Glypican5 is structurally correlated to glypican3 and localized to chromosome 13q32.
Deletion of the 13q region is associated with human 13q syndrome, a developmental disorder [ 24 ] . Some of the proteoglycans play important functional roles in neurogenesis, axon guidance, synapse development [ 25 ] , and cellular growth and differentiation [ 26 27 23 ] . Mutations in GPC3 cause Simpson-Golabi-Behmel syndrome [ 28 29 ] , however, no mutations were detected in the GPC5 and GPC6 genes [ 30 ] . The glypican1 gene has been suggested to be a good candidate for brachydactyly type E [ 31 ] . Given that, GPC5 is highly expressed in brain and mutations in other genes of the glypican families are associated with developmental disorder; GPC5 could be a potential candidate gene for Bipolar disorder.