Words similar to glypican

Example sentences for: glypican

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Deletion of the 13q region is associated with human 13q syndrome, a developmental disorder [ 24 ] . Some of the proteoglycans play important functional roles in neurogenesis, axon guidance, synapse development [ 25 ] , and cellular growth and differentiation [ 26 27 23 ] . Mutations in GPC3 cause Simpson-Golabi-Behmel syndrome [ 28 29 ] , however, no mutations were detected in the GPC5 and GPC6 genes [ 30 ] . The glypican1 gene has been suggested to be a good candidate for brachydactyly type E [ 31 ] . Given that, GPC5 is highly expressed in brain and mutations in other genes of the glypican families are associated with developmental disorder; GPC5 could be a potential candidate gene for Bipolar disorder.
GPC5 belongs to the cell surface heparan sulfate proteoglycan family and is expressed in limb, kidney, developing central nervous system and brain tissue [ 21 22 ] . In vertebrates 6 glypican family members belonging to the proteoglycan family have so far been characterized [ 23 ] . Although there is a high degree of conservation of polypeptide sequence among family members, they are localized to different chromosomes.
Several disorders have been reported due to mutations in glypican gene families [ 31 37 ] and interestingly due to deletion of region on chr.
Glypican5 is structurally correlated to glypican3 and localized to chromosome 13q32.
Human Glypican5: GPC5