Example sentences for: fibroblast

How can you use “fibroblast” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • From four original fibroblast samples, we generated clonally derived cell strains that expressed only the mutant MeCP2 or only the wild-type MECP2 allele, but not both.

  • Second, if the inter-clonal variation we detected by the quantitative RT-PCR study of 5 genes in 22 clones from two different Rett individuals were representative of a general feature of diploid fibroblast clones, it could have masked any consistent biologically meaningful expression changes.

  • Estrogen receptors have been identified in cultured fibroblasts of various origins and vascular smooth muscle cells [ 51 52 53 ] . Estrogens enhance proliferation of fibroblasts and inhibit vascular smooth muscle migration [ 54 55 ] . Binding of estrogens to fibroblasts also stimulates fibroblast interaction with epithelial cells with subsequent acceleration of maturation of epithelial cells [ 56 ] .

  • Previously we have described the interaction of the extracellular domain of proHB-EGF with the second extracellular domain of the tetraspanin protein, monkey CD9 [ 9 ] . Tissue culture experiments using DT-sensitive transfected mouse fibroblast cell lines expressing on the cell surface both the monkey DT receptor and chimeric mouse-monkey CD9 antigen showed that the second extracellular domain of monkey CD9 antigen is able to act as a coreceptor for DT and is also responsible for the increased DT-sensitivity and affinity for DT in these cell lines [ 9 ] . These observations suggested that the CD9 antigen and proHB-EGF likely interact physically on the cell surface.

  • Both these fibroblast lines, although derived from morphologically female genitalia in phenotypically female 46,XY individuals mosaic for AR-inactivating mutations, expressed wild-type AR in the cultured cells.


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