Words similar to fibrinolytic
Example sentences for: fibrinolytic
How can you use “fibrinolytic” in a sentence? Here are some example sentences to help you improve your vocabulary:
Failure to consider the underlying pathophysiologic mechanism when searching for polymorphisms associated with stroke might result in mistaking association for causation [ 2 ] . We studied genes related to thrombosis because the importance of thrombosis in acute ischemic stroke has been established conclusively in numerous clinical trials of treatment and prevention [ 3 4 5 6 7 8 ] . We focused on genetic variations in the fibrinogen gene cluster because of the efficacy of fibrinolytic agents in the acute treatment of ischemic stroke.
The plasminogen activators, tissue type and urokinase type, have been reported to be both deleterious in inflammation, owing to the proteolysis of tissue proteins, and beneficial because of fibrinolytic activity [ 26 ] . The presence of both increased urokinase and plasmin inhibitors in rheumatoid arthritis synovial tissue suggests a complex role for urokinase in this disease [ 27 28 29 ] that seems pertinent to our finding of urokinase-generated mactinin in the arthritis fluid samples.
[ 6 7 8 ] The essential function of PAI-1 in the fibrinolytic system has been confirmed by studies with transgenic animals.
Given the growing evidence that dialysis patients in the modern era may actually be hypercoagulable, primarily due to defects of the fibrinolytic system, [ 25 37 38 ] clinical trials of the use of anticoagulation in atrial fibrillation and thromboembolic disorders are warranted.
BPTI has been used systemically in a few animal tumour models, and showed anti-tumour effects in a mouse hepatoma, lung carcinoma, and mammary carcinoma [ 22 23 24 ] , and in a fibrosarcoma of the hamster [ 24 ] . However, BPTI was not further developed as a systemic anti tumour agent probably because of its anti fibrinolytic property that might preclude its use in cancer patients.
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