Words similar to fibroadenomas

Example sentences for: fibroadenomas

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Sixty-eight frozen human breast tissue specimens were evaluated by LCM, qPCR and IHC, including 31 primary tumors of infiltrating ductal carcinomas (22 primary tumors with metastasis and nine primary tumors without known metastasis), 22 matched nodal metastases, 10 fibroadenomas and five normal breast tissues (obtained from reduction mammoplasty).
Incubation of fibroadenoma and normal breast tissue specimens with the OPN antibody also produced positive staining in the epithelial cells of 53% of nonmalignant cases (five fibroadenomas and three normal breast tissues).
This finding and the observation that fibroadenomas (non-malignant tumors) can express BP1 strongly suggest that its activation might be associated with loss of growth regulation, which is consistent with our molecular data.
We have therefore begun to examine ductal carcinoma in situ (DCIS), which are preinvasive malignant lesions derived from epithelial cells, and fibroadenomas, which are non-malignant tumors composed of epithelial and stromal cells [ 32 33 ] . So far we have analyzed one DCIS, which was BP1-positive, and two fibroadenomas, both of which were BP1-positive, compared with no expression in the matched normal tissue for each fibroadenoma (data not shown).
While benign mammary lesions, usually fibroadenomas, are found in female mice after 7 months of age, few animals develop ductal carcinomas [KP and RP, unpublished; 26], which account for over 85% of human breast cancers.