Example sentences for: fibrinogen

How can you use “fibrinogen” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Binding involves a family of adhesins that interact with extracellular matrix components, and these adhesins have been termed microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) [ 1 ] . Specific MSCRAMMs are responsible for localization of S. aureus to particular tissues, and include fibronectin-binding proteins (FnBPs) [ 2 3 ] , fibrinogen-binding proteins [ 4 5 6 ] , elastin-binding adhesin [ 7 ] collagen-binding adhesion [ 8 ] , and a broad-specificity adhesin (MAP) that facilitates low-affinity binding of S. aureus to several proteins, including osteopontin, collagen, bone sialoprotein, fibronectin, fibrinogen, and vitronectin [ 9 ] . S. aureus can utilize MSCRAMMs to adhere directly to cells or can attach to cells through the use of bridging ligands such as Hsp60 which has an affinity for both MSCRAMMs and the β 1 -integrin host cell receptor [ 10 11 ] . Interaction of S. aureus with host cells via MSCRAMMs can induce signal transduction, tyrosine kinase activity, and cytoskeletal rearrangement [ 12 ] .

  • Previous reports have demonstrated that ADP-ribosylation of B-lymphoid cell lines by C3 treatment inhibits phorbol ester induced cellular homotypic aggregation [ 18 ] . Also, phorbol ester and chemoattractant (IL-8 and fMLP) induced pre-B lymphoblastoid adhesion to VCAM-1 and neutrophil adhesion to fibrinogen was abrogated in a dose-dependent manner by C3 exoenzyme [ 36 ] . This may indicate that in cells of hematopoietic lineages, the induction of an increased adhesive state may be susceptible to regulation by Rho proteins.

  • In the case-control study, the power to address specific issues relating to the genetic associations is dependent on the sample size available, the frequency of the polymorphisms (in the fibrinogen cluster and other candidate genes), and the size of the effect to be detected.

  • For the fibrinogen gene cluster, it is proposed that the genotype be considered as a binary variable, that is, as a single nucleotide polymorphism (SNP) with two possible alleles, since the outcome of polymorphisms in genes of this cluster has resulted in apparent increased risk for ischemic heart disease through increased circulating fibrinogen levels.

  • During the acute phase of inflammatory states, there are quantifiable increases in C-reactive protein, white blood cell count, and fibrinogen, and decreases in serum albumin [5–8].


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