Words similar to endotoxin-induced
Example sentences for: endotoxin-induced
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Recent studies have suggested that phagocytic leukocytes including macrophages and neutrophils contribute to the pathophysiology of endotoxin-induced lung injury [ 22 ] . Whereas macrophages are normally present in the tissue, the majority of neutrophils responding to endotoxin must emigrate into the lung from the blood.
Further studies are needed to determine the precise role of these signaling molecules in endotoxin-induced inflammatory responses in the lung.
Indeed, treatment of the macrophages with the proteasome inhibitor MG132, which prevents NF-κB activation [33], abrogated endotoxin-induced activation of resistin expression (data not shown).
Remarkably, aspirin dramatically decreased endotoxin-induced resistin expression in a dose-dependent manner (Figure 4C).
Moreover, treatment of the macrophages with SN50, a cell-permeable peptide that specifically prevents activation of NF-κB by inhibiting its nuclear translocation [34], nearly abolished endotoxin-induced activation of resistin expression (Figure 4D).
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