Words similar to endothelial
Example sentences for: endothelial
How can you use “endothelial” in a sentence? Here are some example sentences to help you improve your vocabulary:
Endothelial cell culture
It is normally cleared from the blood by macrophages of the reticuloendothelial system predominantly localized in the liver [ 1 ] . Acute endotoxemia, characterized by excessive levels of endotoxin in the blood, can lead to endothelial injury, hypotension, multi-organ failure and death [ 1 ] . Endotoxin-induced tissue injury is associated with an inflammatory response and an accumulation of phagocytes at sites of damage.
Labeled TK-1 cells were then added to the endothelium at a 5:1 lymphocyte: endothelial cell ratio [ 6] and allowed to bind for 30 min under static conditions.
The cell surface expressed integrins can control this process by physically interacting with the extracellular matrix proteins and other cell surface proteins on endothelial cells lining the blood vessel wall [ 1 ] . These integrins signal adhesion and migration by communicating with several tyrosine kinases inside the cell, including the Focal Adhesion Kinase (FAK) and Src family kinases [ 1 2 ] . Src kinases control the activation of FAK, as well as the tyrosine phosphorylation of critical substrates that regulate adhesion and migration [ 3 ] . Indeed, colon cancer cells with high metastatic potential have elevated levels of Src activity or activating mutations in the Src gene [ 4 5 ] . One Src substrate that is involved in regulating an important signaling node in this process is the adaptor protein p130 cas (Cas) [ 6 7 8 9 10 ] . Cas appears to play a central role in the transformation process by several oncogenes including ras, ornithine decarboxylase (ODC), v-Src, v-crk, and Bcr-Abl, as these tumors all have elevated levels of tyrosine phosphorylated Cas [ 6 11 12 13 ] . Cells from mice that lack Cas have much reduced migration and are resistant to transformation by v-Src, while expression of Cas anti-sense RNA in cells transformed with ras, v-Src or ODC result in reversion of the transformed phenotype [ 11 14 15 ] . Furthermore, increased expression of Cas can rescue cell migration and adhesion in cells expressing the tumor suppressor PTEN, and can enhance cell migration and adhesion in normal cells, with a major role being played by the substrate domain [ 16 17 ] .
et al [ 29 ] that TNFα is a potent apoptotic stimulus of primary luteal microvascular endothelial cells and extend these findings by characterizing the activation of several stress-activated signal transduction pathways in response to TNFα treatment of cultured endothelial cells.
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