Words similar to endotoxemia
Example sentences for: endotoxemia
How can you use “endotoxemia” in a sentence? Here are some example sentences to help you improve your vocabulary:
The present studies demonstrate that acute endotoxemia causes increases in the number of adherent neutrophils in the lung vasculature.
The initial step in this process involves tight adherence of the neutrophils to the vasculature [ 23 ] . In this study, we analyzed the effects of acute endotoxemia on functional and biochemical responsiveness of these cells.
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that may play a role in several disease states, including arthritis, sepsis, Crohn's disease, allograft rejection, asthma and prostate cancer [ 1 2 3 ] . Although MIF was initially described as released from activated T-cells [ 4 5 ] , subsequent investigations have localized MIF in a variety of other cells and tissues (for a recent review [ 1 ] ). For example, pre-formed MIF stores can be found in the epithelia of several organs and may be released in response to endotoxemia [ 6 ] . The role of MIF in the central nervous system remains to be determined, yet neurons in the brain synthesize and rapidly release MIF while glial cells appear to store MIF [ 7 8 ] , and the anterior pituitary gland contains MIF that may be released during endotoxemia [ 9 ] .
Acute endotoxemia also rapidly induced NF-κB and CREB, as well as total p38 and p44/42 MAP kinases.
We have previously shown that acute endotoxemia primes adherent lung neutrophils for increased production of reactive oxygen and nitrogen intermediates suggesting that these cells are functionally activated [ 9 ] . The work reported here, demonstrates that adherent vascular lung neutrophils from endotoxin treated rats are also activated to respond to chemotactic stimuli and to express TNF-α and COX-2 mRNA and protein.
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