Words similar to endotoxemia
Example sentences for: endotoxemia
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Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine that may play a role in several disease states, including arthritis, sepsis, Crohn's disease, allograft rejection, asthma and prostate cancer [ 1 2 3 ] . Although MIF was initially described as released from activated T-cells [ 4 5 ] , subsequent investigations have localized MIF in a variety of other cells and tissues (for a recent review [ 1 ] ). For example, pre-formed MIF stores can be found in the epithelia of several organs and may be released in response to endotoxemia [ 6 ] . The role of MIF in the central nervous system remains to be determined, yet neurons in the brain synthesize and rapidly release MIF while glial cells appear to store MIF [ 7 8 ] , and the anterior pituitary gland contains MIF that may be released during endotoxemia [ 9 ] .
Remarkably, resistin levels rose dramatically because of endotoxemia, peaking 8–16 h after LPS administration (Figure 5A).
It is normally cleared from the blood by macrophages of the reticuloendothelial system predominantly localized in the liver [ 1 ] . Acute endotoxemia, characterized by excessive levels of endotoxin in the blood, can lead to endothelial injury, hypotension, multi-organ failure and death [ 1 ] . Endotoxin-induced tissue injury is associated with an inflammatory response and an accumulation of phagocytes at sites of damage.
Animals were housed in microisolator cages and were maintained on sterile food and pyrogen-free water ad libitum . Acute endotoxemia was induced by i.v.
Induction of acute endotoxemia resulted in a dramatic increase in their responsiveness to fMLP, which was evident in cells isolated 0.5 hours after treatment of the animals (Fig.
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