Example sentences for: endothelin

How can you use “endothelin” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Altered vascular function in older individuals is evidenced as impaired endothelial function [ 8 9 10 ] , an altered ratio of endothelin receptors [ 11 ] , and/or altered reactivity of the smooth muscle to sympathetic activity [ 7 12 ] . Reduced endothelial function is related to impaired formation and decreased activation of nitric oxide [ 13 14 ] and is particularly prominent in older subjects with evidence of cardiovascular disease [ 15 ] , diabetes [ 16 ] , or obesity [ 17 ] . Interestingly, aging does not appear to effect endothelium independent vasodilation [ 10 14 ] .

  • Several vasoactive G-protein coupled agonists, including angiotensin II and endothelin, have also been shown to activate the ERK pathway in vascular smooth muscle cells [ 6 21 ] . These same hormones also activate the JNK and p38 pathways.

  • The activation of p38 and JNK pathways by angiotensin II and endothelin occurs at higher concentrations of agonist and requires a longer incubation with the stimulus [ 18 19 25 ] . There are data which also suggest that different signal transduction pathways are utilized for the different pathways [ 25 26 27 ] . This differential activation of MAPK pathways is most likely due to the role that each plays in the cell.

  • In another version of this study published previously, it was seen that ibuprofen reduced the endothelin production induced by endotoxin administration [ 31 ] .


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