Words similar to egfr

Example sentences for: egfr

How can you use “egfr” in a sentence? Here are some example sentences to help you improve your vocabulary:

These results suggest that transactivation of the EGFR does not play a role in δ-OR phosphorylation or ERK activation by δ-opioids.
Several mutations have been identified in the context of epidermal growth factor receptor (EGFR) in patients with NSCLC that are associated with clinical response to the small-molecule EGFR inhibitors gefitinib (Iressa) or erlotinib (Tarceva) [7,8,9], including in-frame deletions such as del L747–E749;A750P in exon 19, or L858R in exon 21.
The effects of EGF on AP-1 protein expression were completely blocked by the EGFR kinase inhibitor tyrphostin AG1478 (data not shown), indicating that growth factor receptor signaling directly correlates with AP-1 protein expression.
In all three patients, we found EGFR mutations associated with drug sensitivity (all exon 19 deletions).
In this report, we questioned whether the EGFR acts as a surrogate scaffold during ERK activation through the δ-OR, as it appears to do for several other GPCRs [ 7 ] . To act as a surrogate-binding site for complex formation, the literature states that this protein must first become tyrosine-phosphorylated [ 7 ] . Tyrosine phosphorylation of the EGFR is apparent after agonist stimulation of the α 2 -AR (COS-7), β 2 -AR (COS-7), insulin-like growth factor (IGF-1; COS-7), substance P, and the lysophosphatidic acid receptor (LPAR) [ 7 ] . In addition, each of the aforementioned ligands also increases ERK phosphorylation when the proper receptor is expressed in these cell lines.