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Example sentences for: dsrnas

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We also provide the first direct evidence that the 21-nt long dsRNAs do not activate a general interferon response.
By 2001, plant scientists working on RNA-directed DNA methylation and TGS had demonstrated a requirement for dsRNAs that are processed to short RNAs, reinforcing a mechanistic link to PTGS (Mette et al.
Interestingly, the IFN response requires long dsRNA [ 5 6 ] , and it has been conjectured that the improved specificity of the 21-nucleotide long dsRNA in cultured mammalian cells is probably due to their inability to activate the IFN response [ 2 ] . We provide several lines of direct and indirect evidence that the dsRNAs described here did not activate a general IFN response.
Lastly, elevated phosphorylation of eIF-2α has been used as a diagnostic marker of IFN response [ 30 ] . We, therefore, examined the phosphorylation status of eIF-2α in A549 cells following transfection with these dsRNAs.
Together, these results directly demonstrate that the dsRNAs promote ablation of the specific mRNA target, which most likely underlies the loss of the respective proteins.