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Example sentences for: dsrnas

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When applied against mRNAs of cytoplasmic RNA viruses, the dsRNAs caused degradation of the specific viral mRNA and resultant ablation of the specific viral protein.
Lastly, elevated phosphorylation of eIF-2α has been used as a diagnostic marker of IFN response [ 30 ] . We, therefore, examined the phosphorylation status of eIF-2α in A549 cells following transfection with these dsRNAs.
The dsRNAs were introduced in cells essentially as described [ 2 ] . Briefly, A549 cells were propagated in standard MEM (Life Technologies) supplemented with 10% fetal bovine serum (FBS) and penicillin-streptomycin.
Together, these results directly demonstrate that the dsRNAs promote ablation of the specific mRNA target, which most likely underlies the loss of the respective proteins.
Second, growth of VSV is known to be highly sensitive to IFN, however, its replication in A549 cells was not affected by any of the dsRNAs described here (data not shown).