Example sentences for: dsrbm

How can you use “dsrbm” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The siRNAs are incorporated into a macromolecular complex which carries out degradation of homologous RNA sequences [ 14 ] . Dicer action serves to inhibit viral infection and retroposon movement, and also plays a role in developmental pathways by cleaving precursors to small regulatory RNAs (reviewed in [ 14 15 ] ). The predicted sequence of the mouse Dicer polypeptide exhibits a single dsRBM and tandem catalytic domains.

  • The polypeptide contains a single dsRBM and two RNase III catalytic domain elements (see Additional File 1).

  • The dsRBM is present in many other proteins that bind dsRNA [ 9 10 ] and is important for RNase III activity in in vitro [ 11 ] . The catalytic domain contains a number of conserved residues, including an 11 amino acid signature motif that is a distinguishing feature of RNase III orthologues.

  • The second mammalian RNase III orthologue also exhibits a single C-terminal dsRBM and tandem catalytic domains, but is otherwise structurally distinct from Dicer as it lacks the helicase and PAZ domains (Figure 1) [ 18 19 ] . Preliminary evidence indicates that this RNase III orthologue participates in rRNA maturation.

  • the two catalytic domains and dsRBM) of the mouse and human sequences exhibit 99% amino acid identity and 88% nucleotide sequence identity.


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