Words similar to dsdna
Example sentences for: dsdna
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The role of Spo11 (Rec12) in the initiation of meiotic recombination via catalysis of dsDNA breaks is conserved and likely universal among eukaryotes.
These nucleases probably contribute to the repair process, in which SSAPs are involved, by providing the initial break in the dsDNA and/or in digesting the nicked target to generate ssDNA.
These proteins are known to cooperate with SbcD, nuclease of the calcineurin-like phosphoesterase superfamily and to degrade dsDNA in the 3' → 5' direction generating ssDNA [ 35 36 ] . It seems likely that RecT/Redβ proteins, at least in certain cases, function in conjunction with the SbcCD-pathway, by utilizing the single-stranded regions generated by the SbcCD nuclease.
Thus, with regard to primary protein sequence (Figure 1), inferred subunit structure (Figure 2and data not shown), strict requirement for meiotic recombination (Figure 2, Table 1), and dependence upon its active site tyrosine (Table 1), Rec12 protein is a structurally and functionally conserved member of the Spo11 family of enzymes that catalyze meiotic dsDNA cleavage to initiate recombination [ 11 ] .
The recE gene product of the Rac prophage converts dsDNA ends into 3' protruding single-stranded form and the recT gene product promotes recombination by annealing them with a homologous DNA in its vicinity (for review, see [ 7 8 ] ). This recombination may result in one progeny DNA (non-conservative recombination) or two progeny DNAs (conservative double-strand break repair) [ 9 ] . In a recBC sbcBC background, a ds end stimulates homologous recombination that results in only one progeny DNA (non-conservative recombination) [ 10 ] . Analysis of the stimulation of recombination by replication (for review, see [ 11 ] ) and analysis of altered chromosomal replication (for review, see [ 12 ] ) led to the proposal that a chromosomal ds break formed during replication fork arrest triggers homologous recombination, which would reconstitute a replication fork (for review, see [ 5 ] ).
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