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Example sentences for: dsrnai

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Moreover, we found that S2 cells treated with dsRNAi against both Arr and Dsh further impaired the Wg and DFz2 signaling activity up to 95% (Figure 2B).
We have attempted to alter the concentrations of components by transient transfection with plasmids encoding wild type and mutant proteins and/or with dsRNAi that can block production of proteins from endogenous or exogenous genes.
Again, Arr dsRNAi markedly inhibited signaling by Wg and DFz2, but no inhibition was observed in the presence of the LRP6 plasmid, implying the LRP6 could substitute for Arr in these synergistic events.
Signaling via LRP6ΔN, however, while dependent on Arm as expected, is not dependent on Dsh or DFz2, as judged by the use of dsRNAi (Figure 5A).
To ask whether LRP6 can replace the requirement for endogenous Arr in the synergy between Wg and DFz2, as observed earlier in Figure 2B, we again used Arr-specific dsRNAi to try to block the strong activation of signaling by Wg plus DFz2, in the presence and absence of the LRP6 constructs (Figure 5C).