Example sentences for: dsh

How can you use “dsh” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Therefore, the interaction between DFz2 and Dsh does not depend solely on the carboxyterminus of DFz2.

  • If the carboxyterminus of LRP6 can interact with Axin independently of DFz2 and Dsh, it might reduce the cytoplasmic level of Axin and help stabilize β-catenin.

  • The secreted glycoproteins in the Wnt/Wingless (Wg) family serve diverse functions in developmental processes, ranging from cell fate specification and cell proliferation to cell migration and cell polarity [ 1 2 ] , and deregulation of the Wnt signaling pathway can lead to cancer [ 3 4 ] . In a simplified model of the canonical Wnt/β-catenin signaling pathway, the binding of Wnts to their receptors activates a downstream component, Dishevelled (Dsh).

  • As additional controls in these experiments, we showed that inhibitory RNA against Dsh, a cytoplasmic phosphoprotein believed to mediate Wg signaling via Fz receptors, blocks about 60% of signaling produced by co-transfection with Wg and DFz2 plasmids.

  • It is known that Dsh is a key component in transducing a Wg signal [ 23 24 25 ] . However, the mechanism by which Dsh transmits a signal to the β-catenin destruction complex is not clear.


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