Words similar to disrupting
Example sentences for: disrupting
How can you use “disrupting” in a sentence? Here are some example sentences to help you improve your vocabulary:
Once gene duplicates have diverged sufficiently so that they differ in their functionality (or non-functionality), gene conversion events can become deleterious—for example, by introducing disrupting mutations from a pseudogene into its functional duplicate.
A gene is “knocked out” (KO) by homologous recombination of a disrupting piece of DNA within that gene.
His job consists of paying off tribal chiefs to prevent them from disrupting pumping operations.
Rab24 contains a unique arginine-rich insert, 126EEDRRRRR 133 [ 25 ] in the domain cognate to loop-8 in H-Ras [ 34 ] . The latter sequence is reminiscent of unusual arginine-rich nuclear localization signals that allow proteins like HIV tet and rev to undergo nuclear translocation by association with importin-β, in the absence of importin-α [ 45 46 ] . Since the loop-8 insert in Rab24 lies adjacent to the conserved N(T)KxD nucleotide binding cassette, we hypothesized that conformational changes caused by the D123I substitution might render the Rab24 mutant capable of disrupting the nuclear import machinery [ 47 ] . To test this possibility, we co-expressed mycRab24wt or mycRab24(D123I) with GR-GFP, a fusion between the glucocorticoid receptor and green fluorescent protein.
About 3 × 10 6pituitary cells infected, or not, 72 h previously with adeno-βgal or adeno-RGS3 were trypsinized, and cell membranes containing the GnRH receptors were prepared by placing the cells in a Dounce homogenizer (Kontes Co., Vineland, NJ) and disrupting them with 30 strokes of the pestle.
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