Example sentences for: disrupt

How can you use “disrupt” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • This frameshift mutation is expected to disrupt the lamin A and C sequences after the first 302 amino acids.

  • Previous studies have shown that Rab24 exhibits several unusual characteristics that distinguish it from other members of the Rab GTPase family [ 25 ] . The studies described in this report demonstrate that putative dominant-negative mutant forms of Rab24, bearing single amino acid substitutions in the conserved N(T)KxD nucleotide binding motif ( e.g. , D123I and T120A), are targeted to numerous inclusion bodies that disrupt the nuclear envelope and enter the nuclear compartment.

  • First, the Rad26-GFP dots were resistant to an extraction method that was developed to specifically-preserve the localization of chromatin-binding proteins [ 42 ] . Secondly, we discovered that the rad26Δ strain is sensitive to TBZ, a phenotype common to mutants that disrupt centromeric-heterochromatin [ 45 ] . Finally, fission yeast has a relatively small number of heterochromatic regions (3 centromeres, 6 telomeres, and 1 mating-type locus; [ 53 54 ] ) and the number of Rad26-GFP dots we observe is roughly consistent with localization to these regions.

  • There are two genes encoding Cct in Drosophila ( Cct1 and Cct2 ), and mutations in the Cct1 gene disrupt patterning during oogenesis (T.

  • Indeed, the expression of dominant negative alleles that can potentially disrupt multiple members of a gene family has been used extensively in Xenopus laevis and has, for example, helped elucidate the action of fibroblast growth factors during mesoderm formation [ 19 ] . Such alleles are particularly useful when a null allele in the same gene causes a disruptive phenotype prior to the stage of development of interest.


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