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Example sentences for: disrupted
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For example, Herschlag and co-workers have previously shown that a nucleobase could complement an abasic site within the hammerhead ribozyme, restoring cleavage activity [ 1 ] . Similarly, Porta and Lizardi engineered a hammerhead ribozyme that assumed an inactive secondary structure; upon the addition of an oligonucleotide that disrupted the engineered secondary structure, the ribozyme was activated [ 2 ] . More recently, it has previously been shown that many selected nucleic acid binding species (aptamers) undergo conformational changes upon ligand binding [ 3 4 5 6 ] In addition, when aptamers are conjoined to ribozymes, the ligand-induced conformational changes in the aptamers frequently modulate the structures and hence the activities of the ribozymes [ 7 8 9 ] For example, binding of theophylline to the anti-theophylline aptamer [ 10 ] modulates the conformation of residue [ 11 12 ] and the overall stability of the aptamer [ 10 13 ] . Appending the anti-theophylline aptamer to the hammerhead ribozyme allowed cleavage activity to be modulated by 110-fold by theophylline [ 13 ] . Similarly, appending the anti-theophylline aptamer to a small ribozyme ligase (L1) generated an aptazyme that was activated 1,600-fold by saturating theophylline concentrations [ 14 ] .
The piece goes on to quote a White House official with Y2K responsibilities complaining that the problem is wrongly viewed as merely an information technology issue, and a California official who warns, "If social services are disrupted, you'll have more than computer problems.
Warned by the CIA that the disrupted Jordanian plot was probably part of a larger series of attacks intended for the millennium, some possibly involving chemical weapons, the Principals Committee met on the night of December 8 and decided to task Clarke's Counterterrorism Security Group (CSG) to develop plans to deter and disrupt al Qaeda plots.
When transfected cells were disrupted in a buffer containing 0.5% NP-40, 0.5% deoxycholate and 0.1% SDS, most of the Rab24(D123I) was recovered in the detergent-insoluble fraction (Fig.
Note that probe A hybridized to a single 4.4-kbp Bgl II fragment in both the parental diploid strain and the heterozygote (Figure 2B, lanes P and H), thereby verifying that it did not detect the disrupted allele.
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