Words similar to disrupted
Example sentences for: disrupted
How can you use “disrupted” in a sentence? Here are some example sentences to help you improve your vocabulary:
In some circumstances, CD4 +and CD8 +T cells were rendered inactive in tumor-bearing hosts [ 8 ] . The inactivation of CD4 +T cells has been attributed either to the tumor cells themselves or to bone marrow-derived cells [ 9 10 11 ] , whereas antigen ignorance or loss of memory have been postulated to underlay that of CD8 +T cells [ 12 13 ] . Other studies have suggested that tumor cells can secrete immunosuppressive factors such as TGF-β or express Fas ligand to induce apoptosis of infiltrating lymphocytes [ 14 15 16 ] . Furthermore, the tumor vasculature appears to be quite different from normal blood vessels, in terms of structural organization, interstitial pressure, and flow patterns [ 17 ] , and in reduced lymphocyte and natural killer cell homing and adhesion [ 18 19 20 21 ] . The existence of significant barriers to effective immunological destruction is further illustrated by a mouse model of concurrent multistage tumorigenesis and anti-oncogene autoimmunity, wherein progenitor dysplastic lesions are infiltrated and disrupted, while solid tumors are not [ 22 ] . The hypothesis is that the microenvironment of certain types of solid tumor can serve to locally suppress T cell infiltration.
Single-gene mutation frequencies are 100-1000 fold higher in cells isolated after gene trap selection than in cells containing randomly integrated retroviruses [ 26 ] . These targeting frequencies also support the idea that retrovirus can integrate throughout the genome and that most, if not all, expressed genes can be disrupted.
In addition, they are consistent with evidence demonstrating that CD5 expression is drastically reduced in gene targeted mice in which the Ets-1 locus is disrupted.
The survival of Lifr -/- pups following RU486 treatment was similar to the phenotype seen in CNTFR null mice where neuronal development was disrupted which disallowed suckling [ 40 ] . This indicates that at least some of the problems encountered with neuronal development that affect normal suckling were not ameliorated by RU486.
We have previously shown that purified threonine558-phosphomoesin selectively co-sedimented with actin filaments in the presence of DOTMAC or PIPs, but excess Triton X-100 disrupted the interaction of moesin with PIPs [ 19].
Loading...