Words similar to disrupts
Example sentences for: disrupts
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A frameshift mutation in the amino-terminal of the BRCA1 gene disrupts the RING domain and all domains after it.
Physiological experiments can also be used to characterize heterochromatin-binding proteins [ 45 ] . For example, absence of Swi6 in fission yeast sensitizes cells to thiabendazole (TBZ), a microtubule depolymerizing drug [ 46 ] . Presumably this occurs because absence of Swi6 disrupts centromeric heterochromatin and, as a result, sensitizes cells to drugs that compromise spindle function.
Tie1 is an orphan receptor, whereas the ligands of Tie2 receptor have been identified as angiopoietin (Ang)-1 and Ang-2 [ 5 6 ] . Ang-1 has been shown to be responsible for recruiting and sustaining periendothelial support cells [ 7 ] . It has been reported that Ang-2 disrupts blood vessel formation in the developing embryo by antagonizing Ang-1-induced autophosphorylation of Tie2 [ 6 ] . Transgenic mouse models of Tie2/Ang-1 result in embryonic lethality due to absence of remodeling and sprouting of blood vessels [ 7 8 ] . The physiologic roles of the Tie2 receptor and its ligands are limited to angiogenic processes that occur subsequently to the earlier vasculogenic and angiogenic actions of vascular endothelial growth factor (VEGF) and its receptors [ 7 ] . VEGF and the Tie family orchestrate optimal blood vessel formation [ 9 10 ] .
These data are reminiscent of prior studies demonstrating that excess endodermal Shh signaling disrupts pancreas development in vivo [16,34].
The 185delAG mutation in the BRCA1 gene disrupts the zinc linker region of the amino-terminal RING domain.
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