Example sentences for: dimerization

How can you use “dimerization” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • It associates specifically with unduplicated centrosomes, and its phosphorylation by CDK-2/cyclin E, the trigger for centrosome duplication, is required for duplication to occur [ 17 ] . The nucleophosmin gene is also known for its fusion with the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase in cases of this disease with (2;5)(p23;q35) translocations [ 18 ] . The nucleophosmin portion contributes to transformation by providing a dimerization domain, which allows activation of the fused kinase and signal transduction [ 19 ] .

  • Although the dimerization we observe may represent a native intersubunit interaction, other possibilities must be considered.

  • Nonetheless, the question regarding the optimal size and composition requirement of this loop for efficient dimerization remains unanswered.

  • Dimerization of the p66 INSsubunit with the wild type p51 (p66 INS/p51 WT) carrying an intact β7-β8 loop resulted in substantial recovery of the RNase H activity.

  • In an earlier investigation on the role of the p51 subunit of HIV-1 RT, we demonstrated that decrease in size of its β7-β8 loop impairs the catalytic function of the heterodimer [ 15 ] . In the present studies, we demonstrate that maintaining the wild type size of this loop in the p51 subunit is critical for dimerization of the enzyme and its catalytic activity.


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