Example sentences for: dimerization

How can you use “dimerization” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • However, insertion of the same amino acid residues in the β7-β8 loop of p51 prevented stable dimerization of the p51 INSsubunit with either p66 INSor p66 WTand adversely impacted the DNA binding, polymerase and RNase H activities.

  • In the case of the EPO agonists, X-ray crystallographic analysis revealed that one of these peptides spontaneously formed non-covalent homodimers that allowed the dimerization of two EPO receptors.

  • Cyclic nucleotide-gated channels, for example, appear to exhibit functional dimerization of their cyclic nucleotide-binding domains [ 32 ] . The "RCK" domain of BK channels has a dimerization domain even though BK channels, too, are tetrameric at the level of the pore [ 33 ] . Finally, the GluR2 ligand-binding core has a dimerization interface in the crystal structure [ 34 ] . Evidence, including the clustering of residues involved in receptor desensitization at this interface, suggests that the dimerization is not just crystallographic but functional.

  • Nonetheless, the question regarding the optimal size and composition requirement of this loop for efficient dimerization remains unanswered.

  • Similarly, dimerization of β-TRCP proteins is mediated by N-terminal "D-domains" lacking binding of SKP1 and other SCF core subunits [ 29 ] . According to our model, the F-box of Pop2p would be essential only for the Pop1p-independent activities of Pop2p, for which we provide tentative evidence by demonstrating the in vivo assembly of SCF Pop2pcomplexes (Fig.


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