Words similar to dimerized

Example sentences for: dimerized

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Two families of small peptides binding to the human thrombopoietin receptor (TPOR) were isolated that competed with the natural ligand TPO [ 34 ] . The peptide with the highest affinity was subsequently dimerized and shown to function as a potent TPO agonist in vivo . Recently, a small, non-peptide organic molecule binding to one chain of the EPO receptor was multimerized and shown to mimic the biological activities of the EPO [ 35 ] .
Interestingly, the DNA binding affinity was restored to the wild type levels, when the mutant p66 subunit was dimerized with the wild type p51 (p66 INS/p51 WT).
Short defined cDNA sequences are initially prepared from mRNA which are then dimerized, multimerized, cloned, and sequenced [ 20 ] . SAGE accelerated the process of gene expression analysis more than an order of magnitude compared to the conventional EST analysis and still is compatible with most of the improvements of DNA sequencing mentioned above.
Interestingly, when the p66 INSmutant was dimerized with the wild type p51 (p66 INS/p51 WT), the polymerase activity was restored to wild type levels.
The same result was obtained when p66 INSwas dimerized with p51 having Asp→Ala mutation at amino acid position 186 (one of the catalytically crucial carboxylate triad) but having an intact β7-β8 loop.