Words similar to dhpr

Example sentences for: dhpr

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In this respect, the contribution of the β1a subunit of the DHPR to EC coupling in skeletal muscle cells has been extensively documented [ 4 22 23 24 ] .
Further, the interactions between DHPR subunits and RyR1 also are incompletely understood.
Such interaction is critical for skeletal DHPR function and is unlikely to occur in heterologous expression systems.
This was shown here by the behavior of the fs-α 1S construct and elsewhere by expressing the N-terminal half (α 1S 1-670) and the C-terminal half (α 1S 701-1873), each with entirely wt sequence and each in a separate expression vector [ 20 ] . The fact that Thr671-Leu690 region known as Peptide A [ 15 ] is missing in fs-α 1S suggests this 20-mer domain is not critical for the conformation change transmitted from the DHPR to the RyR1.
Thus we are certain that the EC coupling expressed by fs-α 1S is mechanistically similar to control skeletal-type EC coupling but limited in magnitude by a comparatively lower density of functional DHPRs that are assembled in cells expressing fs-α 1S . It is conceivable that the functional integrity of the fragmented α 1S protein is maintained in part by the β subunit of the DHPR which spans both halves of the α1 pore subunit by binding to the I-II loop and the C-terminus [ 35 36 ] . Consistent with this explanation, we failed to detect EC coupling recovery when fs-α 1S was expressed in β1-null myotubes.