Words similar to dhpr
Example sentences for: dhpr
How can you use “dhpr” in a sentence? Here are some example sentences to help you improve your vocabulary:
Overall, the γ 1 subunit appears to promote inhibition of the Ca 2+channel function of the skeletal DHPR.
Protein-protein complementation between the N-terminal and C-terminal fragments produced a DHPR capable of functioning as EC coupling voltage sensor, thus suggesting the presence of at least two functional modules within α 1S . Recent evidence suggests that the four internal repeats of the voltage-gated Na +channel, which is closely related to the L-type Ca 2+channel encoded by the DHPR, have non-equivalent functional roles because the S4 segments of repeats I and II move much faster than those of repeats III and IV [ 40 ] . By analogy, the "fast-moving" module of the DHPR would be represented by the N-terminal fragment and the "slower-moving" module by the C-terminal fragment.
Thus we are certain that the EC coupling expressed by fs-α 1S is mechanistically similar to control skeletal-type EC coupling but limited in magnitude by a comparatively lower density of functional DHPRs that are assembled in cells expressing fs-α 1S . It is conceivable that the functional integrity of the fragmented α 1S protein is maintained in part by the β subunit of the DHPR which spans both halves of the α1 pore subunit by binding to the I-II loop and the C-terminus [ 35 36 ] . Consistent with this explanation, we failed to detect EC coupling recovery when fs-α 1S was expressed in β1-null myotubes.
The functional interactions between the DHPR subunits necessary for opening the Ca 2+channel are only partially known.
The impact of the γ 1 null mutation on myotube EC coupling was inferred from intramembrane charge movements, the bulk of which have been shown to originate from the DHPR voltage sensor [ 27, 28].
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