Example sentences for: dhpr

How can you use “dhpr” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The functional interactions between the DHPR subunits necessary for opening the Ca 2+channel are only partially known.

  • While the reason for these discrepancies is unknown, they highlight the fact that in skeletal muscle, the gating characteristics of the L-type Ca 2+channel might be controlled by interactions beyond those taking place among subunits of the DHPR.

  • The mechanism by which the DHPR signals the RyR1 is poorly understood [ 12 13 ] . Domains in the cytoplasmic linker between repeats II and III have been clearly implicated [ 14 15 16 17 18 19 ] , and some regions such as Thr671-Lue690 were suggested to trigger RyR1 opening by binding to RyR1 [ 15 ] . However, extensive deletions within the II-III linker that eliminate the RyR1 binding region, and other suggested signaling regions in the II-III loop [ 16 ] , do not entirely eliminate EC coupling [ 20 21 ] . Hence additional domains of α 1S and/or other DHPR subunits appear to be engaged by the voltage sensor and contribute to an EC coupling signal.

  • Protein-protein complementation between the N-terminal and C-terminal fragments produced a DHPR capable of functioning as EC coupling voltage sensor, thus suggesting the presence of at least two functional modules within α 1S . Recent evidence suggests that the four internal repeats of the voltage-gated Na +channel, which is closely related to the L-type Ca 2+channel encoded by the DHPR, have non-equivalent functional roles because the S4 segments of repeats I and II move much faster than those of repeats III and IV [ 40 ] . By analogy, the "fast-moving" module of the DHPR would be represented by the N-terminal fragment and the "slower-moving" module by the C-terminal fragment.

  • The α 1S pore subunit of the skeletal DHPR is the main determinant of charge movements and EC coupling [ 4, 27, 28].


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