Words similar to dhpr
Example sentences for: dhpr
How can you use “dhpr” in a sentence? Here are some example sentences to help you improve your vocabulary:
Western blots showing the expression of the DHPR subunits are shown in Fig 1D.
Thus we are certain that the EC coupling expressed by fs-α 1S is mechanistically similar to control skeletal-type EC coupling but limited in magnitude by a comparatively lower density of functional DHPRs that are assembled in cells expressing fs-α 1S . It is conceivable that the functional integrity of the fragmented α 1S protein is maintained in part by the β subunit of the DHPR which spans both halves of the α1 pore subunit by binding to the I-II loop and the C-terminus [ 35 36 ] . Consistent with this explanation, we failed to detect EC coupling recovery when fs-α 1S was expressed in β1-null myotubes.
The dihydropyridine receptor (DHPR) of skeletal muscle consists of α 1S , α 2 , β 1a and γ 1 subunits [ 1 ] . The α 1 subunit is a large four-repeat transmembrane protein of ~220 KDa that contains the basic functional elements of the L-type Ca 2+channel, including the Ca 2+selective pore and S4 "voltage-sensing" transmembrane segments in each of the four internal repeats [ 2 ] . β subunits are ~65 kDa cytosolic proteins essential for membrane trafficking, modulation of channel kinetics, and for excitation-contraction (EC) coupling [ 3 4 ] . The α 2 subunit is a highly glycosylated ~175 kDa protein formed by two disulfide-linked peptides [ 5 ] , whereas the γ 1 subunit is a ~32 kDa skeletal muscle-specific protein of four presumptive transmembrane domains with almost unknown function [ 6 7 ] .
The mechanism by which the DHPR signals the RyR1 is poorly understood [ 12 13 ] . Domains in the cytoplasmic linker between repeats II and III have been clearly implicated [ 14 15 16 17 18 19 ] , and some regions such as Thr671-Lue690 were suggested to trigger RyR1 opening by binding to RyR1 [ 15 ] . However, extensive deletions within the II-III linker that eliminate the RyR1 binding region, and other suggested signaling regions in the II-III loop [ 16 ] , do not entirely eliminate EC coupling [ 20 21 ] . Hence additional domains of α 1S and/or other DHPR subunits appear to be engaged by the voltage sensor and contribute to an EC coupling signal.
While this subunit is clearly non-essential for activation of the L-type Ca 2+channel and for triggering skeletal-type EC coupling, γ 1 appears to specifically modulate the Ca 2+channel function of the skeletal DHPR.
Loading...