Words similar to dhplc

Example sentences for: dhplc

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Point mutations can be found in both DMD/BMD male patients and asymptomatic or manifesting DMD/BMD carrier females via an effective and convenient process using automated DHPLC screening for variation and direct sequencing for confirmation and analysis at a moderate increase in cost per patient.
1%) were guanosine at this position in the splice sequence making it likely that exon 68 will be aberrantly spliced [ 23 ] . When these two fragments were run on the DHPLC system at the lower second pass temperatures indicated in Additional file A: Primer sequences and DHPLC temperatures Excel spreadsheet, the alterations were detected (Figure 2cand 2b).
The DHPLC instrument we used is the WAVE ®system (Transgenomic Inc., Omaha, Ne.)
As new mutations are discovered, they could be entered into the database along with any suggested improvements to the DHPLC conditions for a given fragment/alteration.
Although the initial investment in a DHPLC system is not minimal at approximately $80,000, the cost can be amortized over many patients and the DHPLC system can be used in the molecular diagnosis of many other diseases in addition to DMD.