Example sentences for: degraded

How can you use “degraded” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Once this occurs, the mRNA is degraded, effectively silencing the gene from which it came.

  • An alternative mechanism for the formation of inclusion bodies in protein conformation disorders is suggested by a recent study showing that clearance of poly-Gln and poly-Ala inclusions is accelerated by compounds like rapamycin, which stimulate protein degradation by autophagy [ 64 ] . Along similar lines, the work of Kegel et al . [ 65 ] hints that poly-Gln huntingtin may be degraded mainly in autophagic vacuoles containing lysosomal proteases.

  • There are underdogs of a kind in his books--McCoy in Bonfire and the good family man Conrad Hensley in A Man in Full . But what horrifies the reader is that these sympathetic figures should sink into America's degraded lumpenproletariat . The lower orders in Wolfe's novels, such as those who populate the jail where Conrad Hensley is imprisoned, are barely above the level of animals.

  • First, in a separate report, we showed that Smad1 itself is targeted to proteasome and is subsequently degraded by the proteasome, an event that is triggered by the activation of BMP type I receptor and involves the targeting role of Az and HsN3 [ 39 ] . Proteasomal degradation of Smad1 appears to also play a role in regulating the constitutive level of Smad1 in cell as a way to adjust the cellular responsiveness of BMPs [ 47 ] . However, the targeting mechanism and the regulation involved in these two cases of Smad1 degradation by proteasome are likely fundamentally different [ 39 ] . The second functional outcome of the physical link between Smad1, HsN3 and Az is the ability of Smad1 to regulate the proteasomal degradation of SNIP1, which is clearly dependent upon high levels of Smad1, Az and a strong activation signal from the type I receptor, as suggested by the observations that the protein levels of Smad1, Az and ALK3Q233D directly influence the degree of SNIP1 degradation.

  • 2001), most of the protein is not degraded by the ubiquitin-proteasome system.


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