Example sentences for: degrade

How can you use “degrade” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • On the basis of biochemical and immunological criteria, genes have been identified in Globodera rostochiensis and Heterodera glycines that allow these nematodes to endogenously produce enzymes that can degrade cellulose and pectin, the two major components of plant cell walls.

  • Within the MMP family, MMP-1 (collagenase-1) and MMP-13 (collagenase-3) are expressed in arthritic joints, and efficiently degrade type II collagen [ 9 ] . MMP-13 is more effective than MMP-1 in cleaving type II collagen, but it is debated which is the principal collagenase in vivo [ 10 11 ] . These enzymes have been implicated in the pathology of rheumatoid arthritis (RA) and osteoarthritis (OA), and have long been therapeutic targets [ 12 ] . Historically, inhibition of MMP-active sites has been a strategy; however, with wide-ranging side-effects and lack of efficacy, these studies are proving unfruitful in providing an effective drug [ 13 ] .

  • We acknowledge that we have not formally proven this conclusion, but at a minimum, we have demonstrated that the DHBV RNAseH activity cannot degrade exogenous substrates under a very wide variety of conditions that support vigorous activity by the associated DNA polymerase domain.

  • Generally less sensitive than renewal because the toxic substances may degrade or be adsorbed, thereby reducing the apparent toxicity.

  • Mutations in the E2 enzyme Cdc34 or in any of the SCF Cdc4components (Cdc53/Cul1, Skp1 and Cdc4) arrest cells at the G1/S transition because of a failure to degrade the cyclin-dependent kinase (CDK) inhibitor Sic1 [ 3 ] [ 4 ] . In a wild-type situation, G1 cyclin/CDK complexes phosphorylate Sic1 at the end of G1.


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