Example sentences for: degrade

How can you use “degrade” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Tryptophan catabolism by cells expressing IDO is something of an enigma and has resulted in speculation as to why the body requires two enzymes with different tissue specificities to degrade the rarest essential amino acid [ 5, 34].

  • Because the M6P/IGF2R is believed to sequester and degrade IGF-II [ 10 ] , a decrease in M6P/IGF2R could result in decreased degradation and hence increased bioavailability of IGF-II to the IGF-I receptor, which mediates the growth-promoting effect of IGF-II.

  • In addition, chondrocytes produce enzymes, such as the matrix metalloproteinases (MMPs), that degrade the cartilage [ 2 ] . In arthritis, an imbalance of these processes in favour of degradation results in a loss of cartilage.

  • These enzymes include glycosidases, such as lysozymes, that attack the polysaccharide backbone, and peptidases that degrade the cross-linking peptides [ 8].

  • Several lines of evidence suggest that the SCF pathway is also conserved in the fission yeast Schizosaccharomyces pombe . Pcu1p, a Cdc53p/CUL1-related protein, was shown to associate with two different F-box/WD repeat proteins, Pop1p and Pop2p, when overexpressed [ 18 ] . In addition, genetic studies demonstrated that both of these F-box proteins are simultaneously required for efficient destruction of Rum1p and the replication initiator Cdc18p [ 18 19 20 ] . Rum1p is a Sic1p-analogous CDK inhibitor, which accumulates in G1, but is degraded as cells enter S phase [ 21 22 ] . Failure to degrade Rum1p is the major phenotypic defect of pop1 and pop2 deletion strains, which leads to disturbance of normal cell cycle progression, resulting in polyploidy [ 18 19 20 23 ] . Based on the genetic data and the biochemical observation that Pop1p and Pop2p interact when overexpressed, a putative SCF Pop1p-Pop2pcomplex was proposed, which would contain the heterooligomerizing F-box proteins Pop1p and Pop2p bound to SCF core components [ 18 20 ] .


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