Words similar to degradation
Example sentences for: degradation
How can you use “degradation” in a sentence? Here are some example sentences to help you improve your vocabulary:
Az was previously identified as a polyamine-inducible factor that binds and targets the ornithine decarboxylase (ODC) to proteasome for degradation [ 18 45 ] . Until now, ODC is the only protein known to be targeted by Az to proteasome, although the existence of additional proteins targeted by Az to proteasome has been suspected [ 20 ] . We now find two new Az interactors: Smad1, the key signal transducer of BMPs, as well as SNIP1, the nuclear repressor of CBP/p300.
An alternative mechanism for the formation of inclusion bodies in protein conformation disorders is suggested by a recent study showing that clearance of poly-Gln and poly-Ala inclusions is accelerated by compounds like rapamycin, which stimulate protein degradation by autophagy [ 64 ] . Along similar lines, the work of Kegel et al . [ 65 ] hints that poly-Gln huntingtin may be degraded mainly in autophagic vacuoles containing lysosomal proteases.
As shown above and in previous genetic work [ 18 20 ] , SCF Pop1p-Pop2p-dependent Rum1p degradation requires two different proteins with highly conserved F-boxes (Fig.
II 135 in extracts where ubiquitination of RARγ2 can be detected (our unpublished data), at early times we do observe a significant shift in the electrophoretic mobility of TAF II 135 which may correspond to a polyubiquitinated intermediate While the molecular events involved in degradation of transcription factors are in general poorly understood, it is noteworthy that both NRs and TBP have been reported to interact with the proteasome component SUG1 [ [ 60 61 ] ] which may act to target these proteins for degradation.
The spread of nuclear and biological weapons, the growth of international organized crime, and global environmental degradation are a few examples.
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