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Example sentences for: degradation
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LiCl has previously been shown to mimic activation of Wnt-1 signaling by stabilizing beta-catenin through its inhibition of glycogen synthase kinase-3β (GSK-3β), a kinase that phosphorylates beta-catenin and promotes its degradation via the ubiquitin proteasome pathway [ 39 ] . C57mg cells treated with LiCl exhibited elevated levels of mesothelin but not SL-1 (Figure 2, left panel).
Joint sections stained with hematoxylin and eosin were scored for synovitis and bone erosions, as described elsewhere [ 12 13 ] . Sections stained with toluidine blue were scored for cartilage degradation (0, normal staining; 1, some loss of staining; 2, moderate loss of staining; 3, weak staining; 4, very weak staining; 5, no visible staining).
The unglycosylated form of fibronectin is more susceptible to proteolytic degradation than the glycosylated form [ 41 ] . It will be interesting to determine why two forms of myocilin are secreted in humans and what functionality, if any, N-linked glycosylation imparts on human vs. rabbit myocilin.
The growth potential of the eno -and gpmAB - in silico deletion strains was theoretically maintained under aerobic conditions by the synthesis and degradation of serine, and without the serine degradation pathway, the eno -and gpmAB -gene products were defined as essential.
By counteracting Cdk1-mediated phosphorylations, Cdc14 activates both Hct1/Cdh1, which targets Clb2 for degradation [ 3 4 5 ] , and Swi5, which turns on the transcription of Cdk1 inhibitor Sic1 [ 6 3 ] . Degradation of Clb2 and accumulation of Sic1 act in concert to eliminate mitotic Cdk activity, which is required for exit from mitosis [ 7 ] . Thus, elucidating how Cdc14 is regulated holds the key to understanding how cells exit mitosis.
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