Example sentences for: degradation

How can you use “degradation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Several members of the ATP-binding cassette (ABC) superfamily, such as Abca1, are induced via PPARγ and LXRα activation [ 63 ] . Abca1 has been shown to play a role in reverse cholesterol pathways and may be linked to HDL deficiency in metabolic syndromes [ 64 ] . In macrophages, 18:2n6 and AA increased ABCA1 protein degradation without affecting transcriptional levels [ 65 ] . In the current study, Abca1 was significantly decreased by FUNG and FISH.

  • We have previously shown that both net1 tab 2-1and CDC14 TAB 6-1efficiently bypassed the mitotic arrest caused by Tem1-depletion [ 15 18 ] . Furthermore, bypass was accompanied by ectopic Sic1 accumulation and Clb2 degradation.

  • This developmentally important pathway contains several proteins, including APC, Frizzled, Axin and GSK3, which act in concert to promote the proteosomal degradation of β-catenin [ 13 14 ] . When APC is rendered inactive by mutation, β-catenin levels rise and the protein moves into the nucleus where it acts with Tcf/Lef cofactors to regulate transcription of c-myc , cyclin D and other oncogenes [ 15 ] .

  • These observations are consistent with our previous finding that exogenous bovine testicular hyaluronidase PH-20 enhances TNF cytotoxicity in various cancer cells, and that TGF-β1 blocks the increased TNF cytotoxicity [ 8 15 ] . As summarized in the Figure 8, the underlying mechanisms whereby Hyal-2 induces TNF cytotoxicity appear to be associated with 1) Hyal-2 induction of the proapoptotic WOX1, 2) Hyal-2 migration to the mitochondria during apoptosis, and 3) the prolonged period of IκBα degradation and NF-κB activation in TNF-treated Hyal-2-expressing cells.

  • Several of the SBHMs that are specific to the bacterial DDRPs show degradation of the "waist"-like loop of the first internal repeat.


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