Example sentences for: degradation

How can you use “degradation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • Second, the final maturation of the 20S proteasome resulted from the assembly of two half proteasomes into the four stacked ring structure could trap the already bound Smad1 inside the proteasome for rapid degradation or lead to the dissociation of Smad1 from mature 20S proteasome due to the inaccessibility of Smad1 binding site on the incorporated HsN3.

  • Thus, in contrast to Pop1p, Pop2p does not seem, to require its F-box to mediate Rum1p degradation in vivo .

  • It has been proposed that long polyubiquitin chains commit a substrate to unfolding and degradation by the proteasome, whereas short chains are poor substrates because they are edited by deubiquitinating enzymes, resulting in premature substrate release (Eytan et al.

  • Experimental arthritis models have contributed to the basic understanding of joint disease and to the development of effective antiarthritic agents [ 19 ] . Several models have been used to mimic human RA, ranging from immunization with cartilage components to infection with joint trophic organisms [ 20 21 ] . Blocking TNF-α [ 6 22 ] or IL-1 [ 23 24 ] in these models has routinely shown benefit, although some questions remain regarding the role of these cytokines in mitigating joint inflammation versus preventing cartilage degradation and bone erosion [ 25 ] .

  • Other explanations for the presence of statistically significant bands of low M/Z include degradation products of higher molecular weight macromolecules or a matrix effect.


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