Example sentences for: degradation

How can you use “degradation” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The spread of nuclear and biological weapons, the growth of international organized crime, and global environmental degradation are a few examples.

  • 3A,3C) and the degradation of GAG substrates between 0-30 μg was linear.

  • The phosphorylated beta-2 receptor enhances the binding of beta-arrestin, which not only uncouples the receptor from the signal transduction process but also serves as an adapter protein that mediates entry into the internalization pathway [ 5 ] , as well as serving as a platform for additional signaling pathways [ 6 ] . The mechanisms of beta-2 adrenergic receptor down-regulation appear to involve both an increase in the rate of degradation of the receptor as well as a decrease in the levels of beta receptor mRNA [ 7 ] . Down-regulation of the beta-2 receptor is, in part, due to trafficking of the beta-2 receptor to lysosomes via the clathrin-coated pit endosomal pathway [ 8 9 ] .

  • Depletion of TBP and TAF II135 is due to targeted proteolytic degradation

  • The Seven in Absentia (SinA) protein was discovered in Drosophila as a mediator of photoreceptor development [ 29 ] . Subsequently, SinA was shown to participate in the ubiquitin/proteasome pathway [ 30 31 ] . The presence of a RING finger domain in the N-terminus of the mammalian homologue of SinA, "Siah", suggests it may be involved in targeting specific proteins for degradation in the proteasome as a ubiquitin ligase [ 32 ] . Two mammalian genes encoding Siah, Siah1 and 2, are known.


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