Words similar to cyclooxygenase
Example sentences for: cyclooxygenase
How can you use “cyclooxygenase” in a sentence? Here are some example sentences to help you improve your vocabulary:
Inducible cyclooxygenase (COX)-2 expression and eicosanoid production
A portion of liver tissue was also obtained to determine cyclooxygenase (COX) activity.
The cyclooxygenase pathway and NSAIDs have been implicated in pancreatic carcinogenesis, as elevated levels of COX-2 mRNA and protein have been detected in pancreatic carcinomas relative to histologically normal cells [ 14 15 16 17 18 19 ] . Further, both aspirin [ 20 21 22 ] and other NSAIDs [ 19 ] have been shown to inhibit pancreatic cancer cell proliferation and induce apoptosis in vitro . Recent studies have also reported an association between oncogenic ras and COX-2 expression [ 23 24 ] . Since pancreatic tumors tend to exhibit a high frequency of K- ras mutations [ 25 ] , the relationship between the K- ras oncogene and COX-2 should be explored further in vivo.
COX = cyclooxygenase; HF = human fibroblasts; NL = normal lungs; IPF = idiopathic pulmonary fibrosis; IFN = interferon; IL = interleukin; PG = prostaglandin; TX = thromboxane; PGI 2 = prostacyclin.
Many cell types, including lung fibroblasts, contain cyclooxygenase (COX), a proximal enzyme in prostanoid production, and can generate prostanoids [ 19 ] . It has been previously reported that IPF lung fibroblasts have decreased COX-2 expression compared to normal lung fibroblasts and, hence, have decreased PGE 2 production [ 12 20 21 ] . Because of these findings and the fact that PGs are important fibroblast regulators, we sought to investigate whether abnormalities in COX-2 expression could be associated with an altered balance between profibrotic and antifibrotic PGs.
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