Example sentences for: cyclooxygenase

How can you use “cyclooxygenase” in a sentence? Here are some example sentences to help you improve your vocabulary:

  • The cyclooxygenase pathway and NSAIDs have been implicated in pancreatic carcinogenesis, as elevated levels of COX-2 mRNA and protein have been detected in pancreatic carcinomas relative to histologically normal cells [ 14 15 16 17 18 19 ] . Further, both aspirin [ 20 21 22 ] and other NSAIDs [ 19 ] have been shown to inhibit pancreatic cancer cell proliferation and induce apoptosis in vitro . Recent studies have also reported an association between oncogenic ras and COX-2 expression [ 23 24 ] . Since pancreatic tumors tend to exhibit a high frequency of K- ras mutations [ 25 ] , the relationship between the K- ras oncogene and COX-2 should be explored further in vivo.

  • Thus, it appears that ibuprofen has no effect on secreted cyclooxygenase products, as it inhibits the cyclooxygenase enzyme.

  • It has been indicated that the pathway of cyclooxygenase products, such as TxB 2 and PGE 2 , increases in many endotoxic shock models and plays an important role in a number of pathophysiological events [ 21 27 ] .

  • Assessment of cyclooxygenase activity

  • With this inhibition, new production of cyclooxygenase products is blocked.


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