Words similar to cyclin-dependent
Example sentences for: cyclin-dependent
How can you use “cyclin-dependent” in a sentence? Here are some example sentences to help you improve your vocabulary:
Collectively, they have established that the expression of cyclin A and cyclin D, in combination with the activity of the cyclin-dependent kinase inhibitors p21 Cip1and p27 Kip1, is a crucial determinant of anchorage-dependent cell growth culture [ 27 28 29 30 31 32 ] . However, while the above elements clearly are essential executioners of cell cycle progression, it is conceivable that other elements, directly or indirectly, might be involved in anchorage-dependent growth control as well.
P-TEFb contains the cyclin-dependent kinase 9 (CDK9) and one of four possible C-type cyclins.
A plethora of circumstantial evidence implicates downregulation of the cyclin-dependent kinase (CDK) inhibitor p27 in prostate cancer.
Taken together, the significantly enriched classes found for both the A549 and the U118 genes in cell culture compared with tumors are highly indicative of processes of cell division and metabolism, with significant MeSH term classes for the two gene sets including 'Cell cycle' (62 genes for A549, 66 genes for U118), 'DNA replication' (30,33), 'Mitosis' (28,37), 'Mitochondria' (38,52), and 'Cyclin-dependent kinases' (21,30); and significant GO terms including 'Cell proliferation' (36,39), 'Metabolism' (108,134), 'Cytokinesis' (8,6), 'Tricarboxylic acid cycle' (3,5), and 'G1/S transition' (5,7).
When cells harboring conditional-lethal temperature-sensitive (ts) mutations in any of these proteins are shifted to the restrictive temperature, they uniformly arrest in late anaphase as large-budded cells with segregated chromosomes, fully elongated microtubule spindles, and in all tested cases, elevated Cdc28/Clb2 protein kinase activity (Cdc28 is the major cyclin-dependent kinase Cdk1 and Clb2 the major mitosis-specific cyclin of budding yeast) (reviewed in [ 1 ] , [ 2 ] ).
Loading...