Words similar to cyclin-dependent
Example sentences for: cyclin-dependent
How can you use “cyclin-dependent” in a sentence? Here are some example sentences to help you improve your vocabulary:
Collectively, they have established that the expression of cyclin A and cyclin D, in combination with the activity of the cyclin-dependent kinase inhibitors p21 Cip1and p27 Kip1, is a crucial determinant of anchorage-dependent cell growth culture [ 27 28 29 30 31 32 ] . However, while the above elements clearly are essential executioners of cell cycle progression, it is conceivable that other elements, directly or indirectly, might be involved in anchorage-dependent growth control as well.
Mutations in the E2 enzyme Cdc34 or in any of the SCF Cdc4components (Cdc53/Cul1, Skp1 and Cdc4) arrest cells at the G1/S transition because of a failure to degrade the cyclin-dependent kinase (CDK) inhibitor Sic1 [ 3 ] [ 4 ] . In a wild-type situation, G1 cyclin/CDK complexes phosphorylate Sic1 at the end of G1.
Lastly, the cyclin-dependent kinase inhibitor p27 was upregulated by IL-4 in the monkey lung.
A plethora of circumstantial evidence implicates downregulation of the cyclin-dependent kinase (CDK) inhibitor p27 in prostate cancer.
This protein acts as inhibitor of cyclin-dependent kinases (the "cell cycle engine" [ 50 ] ), and its elevated expression has been consistently demonstrated in different cell types after the disruption of cell-matrix interactions (compare Figure 1and [ 31 32 51 52 ] ). Furthermore, p27 Kip1is an established target of PTEN signaling, i.e., its activity has been found increased after the forced expression of exogenous PTEN [ 53 54 55 56 ] . In combination with the data presented in this manuscript, it therefore appears that PTEN contributes to anchorage-dependent growth control by a two-fold approach: the dephosphorylation of the signaling molecule FAK in combination with the stimulation of the cell cycle inhibitor p27 Kip1.
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