Words similar to cyclin-dependent
Example sentences for: cyclin-dependent
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Among cell cycle related proteins, an important role in the regulation of skeletal muscle differentiation belongs to p27 kip1(p27) protein [ 15 ] , a cyclin-dependent kinase inhibitor required for cell cycle arrest.
When cells harboring conditional-lethal temperature-sensitive (ts) mutations in any of these proteins are shifted to the restrictive temperature, they uniformly arrest in late anaphase as large-budded cells with segregated chromosomes, fully elongated microtubule spindles, and in all tested cases, elevated Cdc28/Clb2 protein kinase activity (Cdc28 is the major cyclin-dependent kinase Cdk1 and Clb2 the major mitosis-specific cyclin of budding yeast) (reviewed in [ 1 ] , [ 2 ] ).
p27 is a cyclin-dependent kinase (cdk) inhibitor, and is normally expected to be localized to the cell nucleus.
This protein acts as inhibitor of cyclin-dependent kinases (the "cell cycle engine" [ 50 ] ), and its elevated expression has been consistently demonstrated in different cell types after the disruption of cell-matrix interactions (compare Figure 1and [ 31 32 51 52 ] ). Furthermore, p27 Kip1is an established target of PTEN signaling, i.e., its activity has been found increased after the forced expression of exogenous PTEN [ 53 54 55 56 ] . In combination with the data presented in this manuscript, it therefore appears that PTEN contributes to anchorage-dependent growth control by a two-fold approach: the dephosphorylation of the signaling molecule FAK in combination with the stimulation of the cell cycle inhibitor p27 Kip1.
In fission yeast, the checkpoint rad +genes ( hus1 +, rad1 +, rad3 +, rad9 +, rad17 +and rad26 +) and chk1 +manage the sensing and transducing operations of the DNA damage checkpoint [ 1 16 ] . Current data suggest that the Rad26/Rad3-kinase complex initially senses DNA damage by an unknown mechanism [ 17 ] . This response leads to an increase in the kinase activity of the complex [ 18 ] , which phosphorylates and activates the transducing protein kinase, Chk1 [ 19 ] . Finally, Chk1 delays mitotic entry by targeting Cdc25 and Wee1, regulators of cyclin-dependent kinase activity [ 20 21 22 ] .
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