Words similar to cyclin-dependent

Example sentences for: cyclin-dependent

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Among cell cycle related proteins, an important role in the regulation of skeletal muscle differentiation belongs to p27 kip1(p27) protein [ 15 ] , a cyclin-dependent kinase inhibitor required for cell cycle arrest.
PFD, pelvic floor disorders; p27, p27 kip1; PBS, phosphate-buffered saline; CL, corpus luteum or corpora lutea; cdk, cyclin-dependent kinase; p21, p21 Cip1/WAF1.
Mutations in the E2 enzyme Cdc34 or in any of the SCF Cdc4components (Cdc53/Cul1, Skp1 and Cdc4) arrest cells at the G1/S transition because of a failure to degrade the cyclin-dependent kinase (CDK) inhibitor Sic1 [ 3 ] [ 4 ] . In a wild-type situation, G1 cyclin/CDK complexes phosphorylate Sic1 at the end of G1.
Under conditions favoring proliferation, the phosphorylation of pRB via cyclin-dependent kinases (CDKs) in mid-to-late G 1 phase results in liberation of E2F and other pRB-bound transcription factors, which then activate the transcription of S-phase genes [ 19 ] . In late M phase, pRB returns to its growth suppressive, hypophosphorylated form due to the action of a pRB-directed protein phosphatase belonging to the type 1 class of serine/threonine protein phosphatases [ 11 20 21 ] .
As expected in the case of anchorage-dependent cells, the activity of cyclin-dependent kinases was strongly reduced and cell proliferation was inhibited under these suspension culture conditions (not shown).