Words similar to cyclin-dependent
Example sentences for: cyclin-dependent
How can you use “cyclin-dependent” in a sentence? Here are some example sentences to help you improve your vocabulary:
Cyclin-dependent kinase 2 (cdk2) immunoprecipitates (IP) were utilized as negative controls for ERα monoclonal and ERβ polyclonal antibodies.
Genetic experiments suggested that degradation of Rum1p depends on the Pop1p and Pop2p F-box proteins [ 18 20 ] , but also requires phosphorylation of Rum1p on serine 58 and threonine 62 by cyclin-dependent kinase (CDK) [ 21 ] . Thus, phosphorylated Rum1p may be a substrate for SCF Pop1p-Pop2p-mediated polyubiquitylation.
Taken together, the significantly enriched classes found for both the A549 and the U118 genes in cell culture compared with tumors are highly indicative of processes of cell division and metabolism, with significant MeSH term classes for the two gene sets including 'Cell cycle' (62 genes for A549, 66 genes for U118), 'DNA replication' (30,33), 'Mitosis' (28,37), 'Mitochondria' (38,52), and 'Cyclin-dependent kinases' (21,30); and significant GO terms including 'Cell proliferation' (36,39), 'Metabolism' (108,134), 'Cytokinesis' (8,6), 'Tricarboxylic acid cycle' (3,5), and 'G1/S transition' (5,7).
Cdc2, a catalytic subunit of cyclin-dependent kinases, is required for both the G1-to-S and G2-to-M transitions.
Collectively, they have established that the expression of cyclin A and cyclin D, in combination with the activity of the cyclin-dependent kinase inhibitors p21 Cip1and p27 Kip1, is a crucial determinant of anchorage-dependent cell growth culture [ 27 28 29 30 31 32 ] . However, while the above elements clearly are essential executioners of cell cycle progression, it is conceivable that other elements, directly or indirectly, might be involved in anchorage-dependent growth control as well.
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