Words similar to cyclins
Example sentences for: cyclins
How can you use “cyclins” in a sentence? Here are some example sentences to help you improve your vocabulary:
Recently, flavopiridol was found to inhibit the activity of a transcription elongation factor P-TEFb, a complex of cyclins with CDK9 [ 11].
The results from this study demonstrate down regulation of cyclins, and up-regulation of cyclin inhibitor p21 and IL-10 mRNA expression.
Studies have shown BRCA1 is upregulated in cells treated by DNA damaging agents such as cisplatinum [ 4 ] . BRCA1 has been shown to interact with DNA repair proteins such as Rad50 and Rad51, the tumor suppressor genes RB and BRCA2, transcriptional factors (RNA pol II, histone deacetylase complex, ctIP) as well as influence numerous cyclins and cyclin dependent kinases contributing to cell cycle regulation [ 5 6 7 8 9 10 11 12 ] . More recently, BRCA1 has been shown to influence apoptosis in a p53 independent manner [ 13 ] . This apoptotic response involved the c-jun kinase (JNK) pathway, though the details of this mechanism remain unclear [ 14 ] .
A characteristic phenotype of tumorigenic cells is their ability to grow anchorage-independently in suspension culture, or embedded in soft agar, without the need for attachment to the surface of a cell culture dish [ 25 26 ] . A flurry of papers has established a close link between anchorage-independent growth and the activity of several components of the cell cycle machinery, such as various cyclins, cyclin-dependent kinases (CDKs), and the CDK inhibitors p21 Cip1and p27 Kip1 [ 27 28 29 30 31 32 ] . There are indications that PTEN may be involved in these processes as well.
The results of cyclins G and E mRNA expressed as ratio with β-actin shown in Figure 5. A significant decrease (p < 0.01) in Cyclin G mRNA in lymphocytes from patients treated with TAC and SRL (0.
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