Words similar to cyclins
Example sentences for: cyclins
How can you use “cyclins” in a sentence? Here are some example sentences to help you improve your vocabulary:
This suggests that the HIV-1-induced proliferation of infected renal epithelium may be caused by a cyclin D 1 -dependent mechanism, unlike other viruses that bypass a requirement for G 1 -phase cyclins to trigger aberrant cell-cycle progression.
The APC is a large protein complex that ubiquinates mitotic cyclins and other regulatory proteins that are destined for timely proteolysis by proteasomes [ 10 20 ] . Proteasomes are multicatalytic 26S proteases consisting of a 20S central core catalytic subunit bordered by two 19S components [ 32 33 ] which hydrolyze C-terminal peptide bonds to acidic, basic, and hydrophobic amino-acid residues [ 20 34 ] . Proteasomes proteolyze securins which inhibit separase activity.
We are exploring whether this occurs from enhanced translation of cyclin D 1 message and/or decreased degradation of cyclin D 1 protein and whether other D-type cyclins may be involved in phosphorylating pRb in HIVAN.
In comparison to the two general alternative mechanisms utilized by known transforming viruses to promote cell-cycle progression, namely, by activating or bypassing endogenous D-type cyclins (herein, referred to as "cyclin D"), it has not been established whether HIV-1 gene products trigger either cyclin D-dependent or cyclin D-independent proliferation in non-lymphoid tissues [ 15 ] . In infected renal epithelium, HIV-1 could disrupt the inhibitory binding of pRb to E2F independent of endogenous cyclin D, analogous to transforming viral mechanisms that bypass and down-regulate endogenous cyclin D, such as SV-40 T antigen binding to pRb [ 16 ] , HHV-8 v -cyclin binding to and activating cyclin-dependent kinase-6 (CDK) [ 17 ] , and activation of cyclin E by EBV-induced c -myc [ 18 ] . Alternatively, HIV-1 could activate cyclin D-dependent proliferation, as exemplified by RSV v -src-mediated signaling [ 19 ] . In most tissues, the selective activation of these cell-cycle pathways is readily discernable.
Recently, flavopiridol was found to inhibit the activity of a transcription elongation factor P-TEFb, a complex of cyclins with CDK9 [ 11].
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