Words similar to cyclins
Example sentences for: cyclins
How can you use “cyclins” in a sentence? Here are some example sentences to help you improve your vocabulary:
The APC is a large protein complex that ubiquinates mitotic cyclins and other regulatory proteins that are destined for timely proteolysis by proteasomes [ 10 20 ] . Proteasomes are multicatalytic 26S proteases consisting of a 20S central core catalytic subunit bordered by two 19S components [ 32 33 ] which hydrolyze C-terminal peptide bonds to acidic, basic, and hydrophobic amino-acid residues [ 20 34 ] . Proteasomes proteolyze securins which inhibit separase activity.
Recently, flavopiridol was found to inhibit the activity of a transcription elongation factor P-TEFb, a complex of cyclins with CDK9 [ 11].
A characteristic phenotype of tumorigenic cells is their ability to grow anchorage-independently in suspension culture, or embedded in soft agar, without the need for attachment to the surface of a cell culture dish [ 25 26 ] . A flurry of papers has established a close link between anchorage-independent growth and the activity of several components of the cell cycle machinery, such as various cyclins, cyclin-dependent kinases (CDKs), and the CDK inhibitors p21 Cip1and p27 Kip1 [ 27 28 29 30 31 32 ] . There are indications that PTEN may be involved in these processes as well.
Current study supports our hypothesis that the immunosuppression results in an increased expression of cyclin inhibitor p21, which by inhibiting the expression of cyclins controls the allo-immune activation.
Inhibition of cell cycle by p27 and p21 is complemented by retinoblastoma protein pRb, and other cell cycle inhibitors (tumor suppressor proteins) [ 30 31 32 ] . In reality, besides their role in the regulation of the cell cycle, the cdk inhibitors, in association with D-type cyclins, cyclin E, and cdk2, play a direct role in the stimulation of epithelial cell differentiation [ 33 ] . p27 is also transiently expressed in developing myotomes and enhances myogenesis [ 34 ] .
Loading...