Words similar to cyclin

Example sentences for: cyclin

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In summary, decreased RARα phosphorylation correlating with RA mediated inhibition of cyclin H and cdk7 expression illustrates a new mechanism by which ligand can indirectly regulate receptor activation.
Similarly to nuclear receptors and to other transcription factors, STAT proteins can interact with coactivators to modulate their transcriptional activity [ 9 10 11 12 ] . Other reports have shown direct interactions between several members of the JAK/STAT signaling pathway with SHRs [ 13 14 15 16 ] . Stat3 is one of the seven members of the STAT family of proteins that has been shown to modulate the expression of several genes related to control cell cycle, proliferation and apoptosis, such as Cyclin D1, c-myc, and Bcl-xL, respectively [ 17 ] . Accordingly, alterations in the activity of STAT3 have been associated with cell transformation and cancer progression [ 18 19 20 ] .
Second, de novo synthesis contributes to the pool of cellular p27 Kip1that is available to bind the cyclin E/CDK2 complex.
Moreover, HIV-1-infected podocytes, but not control-infected podocytes, had readily detectable phospho-pRb (Ser780) at the end of the differentiation period, suggesting that the stably up-regulated cyclin D 1 protein remained active in promoting cell-cycle progression (Figure 2B).
Consistent with increased recovery of p27 in cyclin E complexes, MIB caused a concentration and time-dependent increase in steady-state p27 protein levels (Fig.