Words similar to cyclin
Example sentences for: cyclin
How can you use “cyclin” in a sentence? Here are some example sentences to help you improve your vocabulary:
These observations indicate that cytoplasmic expression of p27 correlates with that of cyclin D1.
Here, we ask whether infected podocytes expressing HIV-1 genes show the hallmarks of cyclin D 1 -dependent proliferation, specifically the up-regulation of cyclin D 1 transcript and protein expression and the subsequent phosphorylation of pRb on serine 780, a target site of active cyclin D 1 /CDK-4/6 that is not shared with cyclin E/CDK-2 complexes [ 24 ] . Utilizing two well-characterized models of HIVAN pathogenesis, HIV-1 transgenic mice [ 11 12 13 ] and HIV-1 infection of cultured podocytes [ 6 7 8 ] we find not only these hallmarks of cyclin D 1 -dependent proliferation, but also dysregulation of cyclin D 1 expression that normally occurs with cell-cell contact and differentiation [ 25 ] .
Following 7.5% SDS/PAGE, podocyte protein (20 μg) was analyzed by western blot for cyclin D 1 (ECL detection of a 1:1000 dilution of rabbit anti-cyclin D 1 antibody, Santa Cruz BioTechnology).
Calpain activity is needed for proteolysis of the c-mos proto-oncogene product pp39 mos in Xenopus oocytes [ 51 ] , certain cytoskeletal proteins (alpha-tubulin, actin, dynamin, lamin B) in starfish oocytes [ 52 ] , and of cyclin in Xenopus egg extracts [ 53 ] .
ERα enhances AP-1 activity in response to estrogens, [ 28 29 ] but ERβ inhibits AP-1 activity in response to estrogens [ 29 30 31 ] . ERβ also completely suppresses ERα activity at the cyclin D1 promoter and even suppresses the activity of an ERα mutant that is selectively superactive at AP-1 sites and CREs [ 29 ] . Finally, ERβ shows a unique capacity to enhance AP-1 activity in response to selective estrogen receptor modulators (SERMs) such as raloxifene, tamoxifen and ICI 182,780/Faslodex (ICI) [ 30 31 32 ] . Together, these observations suggest that there are fundamental differences in the way that the ERs bind unspecified cofactors that modulate gene expression, and that some of these cofactors must play a role in differential ER activity at AP-1 sites.
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