Words similar to cyclin
Example sentences for: cyclin
How can you use “cyclin” in a sentence? Here are some example sentences to help you improve your vocabulary:
ERα enhances AP-1 activity in response to estrogens, [ 28 29 ] but ERβ inhibits AP-1 activity in response to estrogens [ 29 30 31 ] . ERβ also completely suppresses ERα activity at the cyclin D1 promoter and even suppresses the activity of an ERα mutant that is selectively superactive at AP-1 sites and CREs [ 29 ] . Finally, ERβ shows a unique capacity to enhance AP-1 activity in response to selective estrogen receptor modulators (SERMs) such as raloxifene, tamoxifen and ICI 182,780/Faslodex (ICI) [ 30 31 32 ] . Together, these observations suggest that there are fundamental differences in the way that the ERs bind unspecified cofactors that modulate gene expression, and that some of these cofactors must play a role in differential ER activity at AP-1 sites.
First, downregulation of cyclin D1 leads to release of p27 Kip1sequestered by the cyclin D1/CDK4 complex.
The histone genes repressed in M/G1 were upregulated in S. In G2 and M, CLB1 (G2/M-specific cyclin involved in mitotic induction), CDC5 (mitotic DNA replication) and CLB2 (G2/M-specific cyclin involved in mitotic induction) were selected as upregulated, in phase M CDC20 (cyclin degradation, part of the anaphase-promoting complex).
Second, de novo synthesis contributes to the pool of cellular p27 Kip1that is available to bind the cyclin E/CDK2 complex.
[ 11 12 13 14 ] . Kidney transplants between normal and transgenic Tg26 siblings suggested that specific HIV-1 proteins within the kidney, and not circulating factors, transform infected renal epithelium [ 13 ] . Indeed, HIV-1 transgenic mice generated with an HIV-1 proviral construct mutated in the Nef "PXXP" SH3-binding motif for Src-family kinases failed to develop nephropathy [ 31 ] , and a recent in vitro analysis of podocytes infected with single gene mutants of HIV-1 further suggest that Nef plays a central role in causing the proliferative phenotype in HIVAN [ 8 ] . Utilizing these same single gene mutant viruses, we showed here that Nef appears to be play a role in the up-regulation of cyclin D 1 by HIV-1 in vitro . Importantly, these single gene mutants do not exclude the possibility that other HIV-1 gene(s) may cooperate with nef to induce cyclin D1, particularly
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