Words similar to cyclin
Example sentences for: cyclin
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[ 11 12 13 14 ] . Kidney transplants between normal and transgenic Tg26 siblings suggested that specific HIV-1 proteins within the kidney, and not circulating factors, transform infected renal epithelium [ 13 ] . Indeed, HIV-1 transgenic mice generated with an HIV-1 proviral construct mutated in the Nef "PXXP" SH3-binding motif for Src-family kinases failed to develop nephropathy [ 31 ] , and a recent in vitro analysis of podocytes infected with single gene mutants of HIV-1 further suggest that Nef plays a central role in causing the proliferative phenotype in HIVAN [ 8 ] . Utilizing these same single gene mutant viruses, we showed here that Nef appears to be play a role in the up-regulation of cyclin D 1 by HIV-1 in vitro . Importantly, these single gene mutants do not exclude the possibility that other HIV-1 gene(s) may cooperate with nef to induce cyclin D1, particularly
For instance, an action link (iconified as a wall plug) allows the calcium-dependent activation of calmodulin in Figure 4to inhibit the export of cyclin D1 from the nucleus in Figure 3. Identity links, on the other hand, allow models to share a common icon and its properties.
Cyclin A, but not cyclin E levels were also suppressed by MIB in an AR-dependent manner, while the levels of the COP9/signalosome subunit CSN5/JAB1 and tubulin remained constant (Fig.
The genes CA 9 ( carbonic anhydrase IX ), CCND1 ( cyclin D1 ), CDH2 ( N-Cadherin ), EGFR ( epidermal growth factor receptor ) and TGFA ( tranforming growth factor alpha ) all showed increases in CC expression that matched the literature and had p-values ≤ 0.0061 [ 11 12 13 14 15 ] . The observed decrease in CDH1 ( E-cadherin ) in CC (p-value = 0.0045) also matched previously published reports, as did the decrease in VIM ( vimentin ) expression in Chr RCCa [ 13 16 ] . VIM was also found to be increased in CC with a p-value = 0.0045, which was consistent with the literature.
Loss of Hnt1 enzymatic activity also renders cells hypersensitive to mutations in the cyclin H homolog Ccl1, the MAT1 homolog Tfb3, and to Cak1, the activating kinase for Kin28, all of which lead to destabilized Kin28 complexes and a likely increase in concentration of Kin28 monomers [ 30].
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